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Metabotropic glutamate receptor mediated synaptic plasticity in the bed nucleus of the stria terminalis as a target for stress, anxiety and addiction disorders
(2006-01-20)
The importance of integration of information from neurocircuits innervating the reward circuitry is becoming increasingly recognized. For instance, the roles of stress/anxiety pathways in modulating specific effects of ...
An ensemble recruited by α2a-adrenergic receptors is engaged in a stressor-specific manner in mice
(2022-11-14)
α2a-adrenergic receptor (α2a-AR) agonists are candidate substance use disorder therapeutics due to their ability to recruit noradrenergic autoreceptors to dampen stress system engagement. However, we recently found that ...
Laughter and Amusement’s Buffering Effect on Stress in a Population with Symptoms of Anxiety: An Experimental Design
(2016-04-08)
Anxiety and stress can have debilitating effects on our physical and mental health. The purpose of the current study was to examine a way to buffer, or protect, people with anxious symptoms from the negative affect produced ...
The Endocannabinoid, 2-arachidonoylglycerol, Regulates Resilience to Stress-induced Anxiety
(2017-04-10)
Nearly 30% of the global burden of nonfatal disease is due to affective disorders. Stress is a potent risk factor for affective disorders including major depression and posttraumatic stress disorder. The neurobiological ...
Stress- and Drug-Dependent Regulation of Metabotropic Glutamate Receptors in the Bed Nucleus of the Stria Terminalis
(2011-04-15)
Metabotropic glutamate receptors (mGluRs) are important modulators of excitatory transmission throughout the central nervous system, and have been implicated in a variety of neurological disorders. This work focuses ...
Endocannabinoid Augmentation Through Substrate-Selective COX-2 Inhibition: Behavioral and Synaptic Effects In An Animal Model of Stress-Induced Anxiety
(2016-08-01)
Cannabinoid receptors have been examined as potential targets to alleviate the negative consequences of anxiety, trauma-related, and stress-related disorders. However, in preclinical animal studies, synthetic cannabinoids ...
Recurrent Abdominal Pain, Anxiety, and Responses to Stress in Children and Adolescents
(2008-05-20)
Recurrent abdominal pain (RAP) is the most common type of recurrent pediatric pain. Much evidence shows that this condition adversely affects many areas of a child’s functioning, including repeated school problems and ...
Effects of Acute and Chronic Stress on Attention and Psychobiological Stress Reactivity in Women
(2012-08-12)
The current study investigated the role of chronic stress in alterations in automatic attentional and stress reactivity processes that may affect vulnerability to mental and physical illness in women. Participants were ...
Endocannabinoid Signaling at Distinct Regions and Circuits Bidirectionally Modulates Stress: Implications for Cannabis Treatments in Psychiatric Disorders
(2023-03-29)
The endocannabinoid (eCB) system, which consists of the cannabinoid receptor type 1 (CB1R) and its endogenous ligand, 2-arachidonoylglycerol (2-AG), as well as key synthesis and degradation enzymes, can promote bidirectional, ...