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Diffusion Magnetic Resonance Imaging of the Human Spinal Cord in Vivo: Feasibility and Application of Advanced Diffusion Models
(2017-08-24)
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) that is marked by inflammation, demyelination, gliosis and axonal loss. The damage to the CNS from these mechanisms can result in an ...
Quantitative proton relaxometry in the rotating frame with magnetic resonance imaging
(2011-08-30)
Conventional magnetic resonance imaging (MRI) uses contrast that is weighted by the intrinsic tissue parameters T1, and T2. Contrast may also be generated in the rotating frame with the analogous time constants T1ρ or T2ρ. ...
Intracranial Hemodynamic Compensation Mechanisms in Patients with Cerebrovascular Disease
(2017-09-25)
Cerebrovascular disease (CVD) encompasses conditions that affect the blood supply to the brain. CVD results in hemodynamic impairment, and when the brain can no longer compensate for decreased oxygen delivery to tissue, ...
Improved Assessment of Reading Networks in the Brain Using Diffusion MRI
(2013-04-01)
Reading is a complex cognitive behavior, which relies on the incorporation of a network of brain regions. White matter is the information transfer pathway between distant brain regions, and thus plays an important role in ...
Towards quantitative measurements of tissue microstructure using temporal diffusion spectroscopy
(2015-07-06)
Diffusion MRI provides a non-invasive means to characterize tissue microstructure at varying length scales. Apparent diffusion coefficients (ADCs) of tissue water may be measured at relatively long diffusion times with ...
Harnessing Non-invasive Imaging and Modeling towards Early Detection of Tumor Resistance to Targeted Therapy
(2017-02-03)
Clinical imaging and biopsies are major tools for cancer diagnosis. We explore whether serial imaging coupled with a mathematical model could test and refine patient specific forecasts for therapy outcomes.
We first ...
Imaging and Genetics of Two Amyloid Related Diseases: Alzheimer’s Disease and Down Syndrome
(2014-02-20)
Alzheimer’s Disease is an irreversible, degenerative disease of the brain that accounts for a majority of dementia cases each year, in both the general population and in patients with Down Syndrome. The advancement of in ...
Experimental Evaluation of Advanced Diffusion MRI Methods Towards Improved Assessment of Myelinated Neural Tissue
(2017-02-09)
Diffusion-weighted MRI (DWI) techniques have demonstrated the ability to non-invasively assess normal and pathological neural tissue. Recently-developed advanced DWI methods have the potential to provide quantitative ...
Correction of image distortion in echo planar image series using phase and intensity
(2008-02-22)
Among all magnetic resonance imaging sequences, gradient-echo (GE) echo-planar imaging (EPI) has become the most common technique for the study of dynamic brain function and for other high-speed applications like cardiac ...
Validation of diffusion tensor imaging in the central nervous system using light microscopy
(2010-09-23)
Diffusion tensor imaging (DTI) provides an indirect measure of tissue structure on microscopic scales. To date, DTI is the only imaging method that provides such information in vivo, and it has proven to be a valuable tool ...