• Scavenging dicarbonyls with 5'-O-pentyl-pyridoxamine increases HDL net cholesterol efflux capacity and attenuates atherosclerosis and insulin resistance 

  Huang, Jiansheng; Tao, Huan; Yancey, Patricia G.; Leuthner, Zoe; May-Zhang, Linda S.; Jung, Ju-Yang; Zhang, Youmin; Ding, Lei; Amarnath, Venkataraman; Liu, Dianxin; Collins, Sheila; Davies, Sean S.; Linton, MacRae F. (Molecular Metabolism, 2023-01-13)

  Objective: Oxidative stress contributes to the development of insulin resistance (IR) and atherosclerosis. Peroxidation of lipids produces reactive dicarbonyls such as Isolevuglandins (IsoLG) and malondialdehyde (MDA) that ...
• Clinical Implications of the New York Heart Association Classification 

  Lindenfeld, Joanne (Journal of the American Heart Association, 2019-12-03)

  Background The New York Heart Association (NYHA) classification has served as a fundamental tool for risk stratification of heart failure (HF) and determines clinical trial eligibility and candidacy for drugs and devices. ...
• Impact of Palliation Strategy on Interstage Feeding and Somatic Growth for Infants With Ductal-Dependent Pulmonary Blood Flow: Results from the Congenital Catheterization Research Collaborative 

  Nicholson, George T. (2020-01-07)

  Background In infants with ductal-dependent pulmonary blood flow, the impact of palliation strategy on interstage growth and feeding regimen is unknown. Methods and Results This was a retrospective multicenter ...
• International Consortium for Health Outcomes Measurement (ICHOM): Standardized Patient-Centered Outcomes Measurement Set for Heart Failure Patients 

  Stevenson, Lynne W. (JACC-Heart Failure, 2020-03)

  Whereas multiple national, international, and trial registries for heart failure have been created, international standards for clinical assessment and outcome measurement do not currently exist. The working group's objective ...
• Reverse Cardio-Oncology: Cancer Development in Patients With Cardiovascular Disease 

  Aboumsallem, Joseph Pierre; Moslehi, Javid; de Boer, Rudolf A. (Journal of the American Heart Association, 2020-01-21)
• Sex hormone exposure and reproductive factors in pulmonary arterial hypertension: a case-control study 

  Badlam, Jessica B.; Badesch, David; Brittain, Evan; Cordell, Shannon; Ding, Tan; Fox, Kelly; Hemnes, Anna; Loyd, James; Pugh, Meredith; Robbins, Ivan; Yu, Chang; Austin, Eric D. (Pulmonary Circulation, 2020-01)

  Pulmonary arterial hypertension (PAH) is a sexually dimorphic disease that for unknown reasons affects women more than men. The role of estrogens, both endogenous and exogenous, and reproductive factors in this female ...
• Low-Dose Aspirin for Primary Prevention of Cardiovascular Disease: Use Patterns and Impact Across Race and Ethnicity in the Southern Community Cohort Study 

  Fernandez-Jimenez, Rodrigo; Wang, Thomas J.; Fuster, Valentin; Blot, William J. (2019-12-17)

  Background Data are limited on use patterns of low-dose aspirin and its role for primary prevention of cardiovascular disease (CVD) in different racial and ethnic groups. Methods and Results Overall, 65 231 ...
• A multifaceted investigation into molecular associations of chronic thromboembolic pulmonary hypertension pathogenesis 

  Halliday, Stephen J.; Matthews, Daniel T.; Talati, Megha H.; Austin, Eric D.; Su, Yan R.; Absi, Tarek S.; Fortune, Niki L.; Gailani, David; Matafonov, Anton; West, James D.; Hemnes, Anna R. (JRSM Cardiovascular Disease, 2020-02)

  Purpose Chronic thromboembolic pulmonary hypertension is characterized by incomplete thrombus resolution following acute pulmonary embolism, leading to pulmonary hypertension and right ventricular dysfunction. Conditions ...
• Effects of Interleukin-1 beta Inhibition on Blood Pressure, Incident Hypertension, and Residual Inflammatory Risk A Secondary Analysis of CANTOS 

  Rothman, Alexander M. K.; MacFadyen, Jean; Thuren, Tom; Webb, Alastair; Harrison, David G.; Guzik, Tomasz J.; Libby, Peter; Glynn, Robert J.; Ridker, Paul M. (Hypertension, 2020-02)

  While hypertension and inflammation are physiologically inter-related, the effect of therapies that specifically target inflammation on blood pressure is uncertain. The recent CANTOS (Canakinumab Anti-inflammatory Thrombosis ...
• 2019 HRS/EHRA/APHRS/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias 

  Stevenson, William G. (Heart Rhythm, 2020-01)

  Ventricular arrhythmias are an important cause of morbidity and mortality and come in a variety of forms, from single premature ventricular complexes to sustained ventricular tachycardia and fibrillation. Rapid developments ...
• PCSK9 Inhibitor Use in the Real World: Data From the National Patient-Centered Research Network 

  Song, Wen-Liang; Linton, MacRae F. (Journal of the American Heart Association, 2019-05-07)

  Background-PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors effectively lower LDL (low-density lipoprotein) cholesterol and have been shown to reduce cardiovascular outcomes in high-risk patients. We used ...
• Trajectories of Blood Lipid Concentrations Over the Adult Life Course and Risk of Cardiovascular Disease and All-Cause Mortality: Observations From the Framingham Study Over 35 Years 

  Duncan, Meredith S.; Vasan, Ramachandran S.; Xanthakis, Vanessa (Journal of the American Heart Association, 2019-06-04)

  Background-Elevated total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides, and non-high-density lipoprotein cholesterol (non-HDL-C) and low high-density lipoprotein cholesterol (HDL-C) ...
• Prevalence of Cardiovascular Disease Risk Factors in Childhood Glomerular Diseases 

  Hunley, T.E. (Journal of the American Heart Association, 2019-07-16)

  Background-Cardiovascular disease is a major cause of morbidity and mortality in children with chronic kidney disease. We sought to determine the prevalence of cardiovascular risk factors in children with glomerular disease ...
• Apolipoprotein E Genotype Modifies the Association Between Cardiac Output and Cognition in Older Adults 

  Bown, Corey W.; Liu, Dandan; Osborn, Katie E.; Gupta, Deepak K.; Mendes, Lisa A.; Pechman, Kimberly R.; Hohman, Timothy J.; Wang, Thomas J.; Gifford, Katherine A.; Jefferson, Angela L. (Journal of the American Heart Association, 2019-08-06)

  Background-Subtle reductions in cardiac output relate to lower cerebral blood flow, especially in regions where Alzheimer's disease pathology first develops. Apolipoprotein E (APOE)-epsilon 4 is a genetic susceptibility ...
• Is There A Role for Electronic Cigarettes in Tobacco Cessation? 

  Bhatnagar, Aruni; Payne, Thomas J.; Robertson, Rose Marie (Journal of the American Heart Association, 2019-06-18)
• Proteomics Profiling and Risk of New-Onset Atrial Fibrillation: Framingham Heart Study 

  Ko, Darae; Benson, Mark D.; Ngo, Debby; Yang, Qiong; Larson, Martin G.; Wang, Thomas J.; Trinquart, Ludovic; McManus, David D.; Lubitz, Steven A.; Ellinor, Patrick T.; Vasan, Ramachandran S.; Gerszten, Robert E.; Benjamin, Emelia J.; Lin, Honghuang (Journal of the American Heart Association, 2019-03-19)

  Background-Prior studies relating proteomics markers to incident AF screened for limited numbers of proteins. Methods and Results-We performed proteomics assays among participants from the Framingham Heart Study Offspring ...
• Natural History of Cardiomyopathy in Adult Dogs With Golden Retriever Muscular Dystrophy 

  Guo, Lee-Jae; Soslow, Jonathan H.; Bettis, Amanda K.; Nghiem, Peter P.; Cummings, Kevin J.; Lenox, Mark W.; Miller, Matthew W.; Kornegay, Joe N.; Spurney, Christopher F. (Journal of the American Heart Association, 2019-08-20)

  Background-Duchenne muscular dystrophy (DMD) is an X-linked disease that causes progressive muscle weakness. Affected boys typically die from respiratory or cardiac failure. Golden retriever muscular dystrophy (GRMD) is ...
• Interaction of alpha Carboxyl Terminus 1 Peptide With the Connexin 43 Carboxyl Terminus Preserves Left Ventricular Function After Ischemia-Reperfusion Injury 

  Jiang, Jingbo; Hoagland, Daniel; Palatinus, Joseph A.; He, Huamei; Iyyathurai, Jegan; Jourdan, L. Jane; Bultynck, Geert; Wang, Zhen; Zhang, Zhiwei; Schey, Kevin; Poelzing, Steven; McGowan, Francis X.; Gourdie, Robert G.) (Journal of the American Heart Association, 2019-08-20)

  Background-alpha Carboxyl terminus 1 (alpha CT1) is a 25-amino acid therapeutic peptide incorporating the zonula occludens-1 (ZO-1)-binding domain of connexin 43 (Cx43) that is currently in phase 3 clinical testing on ...
• Echocardiographic Detection of Occult Diastolic Dysfunction in Pulmonary Hypertension After Fluid Challenge 

  Agrawal, Vineet; (D'Alto, Michele; Naeije, Robert; Romeo, Emanuele; Xu, Meng; Assad, Tufik R.; Robbins, Ivan M.; Newman, John H.; Pugh, Meredith E.; Hemnes, Anna R.; Brittain, Evan L. (Journal of the American Heart Association, 2019-09-23)

  Background-Identification of occult diastolic dysfunction often requires invasive right heart catheterization with provocative maneuvers such as fluid challenge. Non-invasive predictors of occult diastolic dysfunction have ...
• Why has positive inotropy failed in chronic heart failure? Lessons from prior inotrope trials 

  Ahmad, Tariq; Miller, P. Elliott; McCullough, Megan; Desai, Nihar R.; Riello, Ralph; Psotka, Mitchell; Boehm, Michael; Allen, Larry A.; Teerlink, John R.; Rosano, Giuseppe M. C.; Lindenfeld, JoAnn (European Journal of Heart Failur, 2019-09)

  Current pharmacological therapies for heart failure with reduced ejection fraction are largely either repurposed anti-hypertensives that blunt overactivation of the neurohormonal system or diuretics that decrease congestion. ...

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