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Safety, tolerability, and pharmacokinetics of repeated oral doses of 2-hydroxybenzylamine acetate in healthy volunteers: a double-blind, randomized, placebo-controlled clinical trial
(BMC Pharmacology & Toxicology, 2020-01-06)
Background 2-Hydroxybenzylamine (2-HOBA) is a selective dicarbonyl electrophile scavenger being developed as a nutritional supplement to help protect against the development of conditions associated with dicarbonyl ...
Semantic Memory and the Hippocampus: Revisiting, Reaffirming, and Extending the Reach of Their Critical Relationship
(Frontiers in Human Neuroscience, 2020-01-24)
Since Tulving proposed a distinction in memory between semantic and episodic memory, considerable effort has been directed towards understanding their similar and unique features. Of particular interest has been the extent ...
Novel Human NKCC1 Mutations Cause Defects in Goblet Cell Mucus Secretion and Chronic Inflammation
(Cellular and Molecular Gastroenterology and Hepatology, 2020)
BACKGROUND & AIMS: Infections resulting from intestinal yeast and bacteria affect a large number of patients with deficits in absorptive or secretory epithelial transport mechanisms. The basolateral Na+-K+-2Cl(-) cotransporter ...
Association between financial links to indoor tanning industry and conclusions of published studies on indoor tanning: systematic review
(BMJ-British Medical Journal, 2020-02-05)
OBJECTIVE
To assess whether an association exists between financial links to the indoor tanning industry and conclusions of indoor tanning literature.
DESIGN
Systematic review.
DATA SOURCE
PubMed, Embase, ...
LATS Dance: Molecular Choreography Between a Chronic Human Pathogen and Its Host
(Cellular and Molecular Gastroenterology and Hepatlogy, 2020)
Pharmacokinetic-tailored approach to hemophilia prophylaxis__Medical decision making and outcomes
(Research and Practice in Thrombosis and Haemostasis, 2020-02)
Background Clinical application of population pharmacokinetics (popPK) is of increasing interest to patients with hemophilia, providers, and payers. Routine use of popPK profiles in factor replacement prophylaxis decision ...
Mislocalized cytoplasmic p27 activates PAK1-mediated metastasis and is a prognostic factor in osteosarcoma
(Molecular Oncology, 2020-02)
The development of pulmonary metastasis is the leading cause of death in osteosarcoma (OS), which is the most common malignant bone tumor in children. We have previously reported that the tumor suppressor p27 (KIP1, CDKN1B) ...
The Prevalence and Clinical Implications of Comorbid Back Pain in Shoulder Instability: A Multicenter Orthopaedic Outcomes Network (MOON) Shoulder Instability Cohort Study
(Orthopaedic Journal of Sports Medicine, 2020-02)
Background:
Understanding predictors of pain is critical, as recent literature shows that comorbid back pain is an independent risk factor for worse functional and patient-reported outcomes (PROs) as well as increased ...
P-31 magnetic resonance spectroscopy in skeletal muscle: Experts' consensus recommendations
(NMR in Biomedicine, 2020-02)
Skeletal muscle phosphorus-31 P-31 MRS is the oldest MRS methodology to be applied to in vivo metabolic research. The technical requirements of P-31 MRS in skeletal muscle depend on the research question, and to assess ...
Post-GWAS analysis of six substance use traits improves the identification and functional interpretation of genetic risk loci
(Drug and Alcohol Dependence, 2020-01)
Background: Little is known about the functional mechanisms through which genetic loci associated with substance use traits ascertain their effect. This study aims to identify and functionally annotate loci associated with ...