Isolation and Characterization of Anti-malarial Compounds from a Natural Product Library
dc.creator | Carrell, Holly Marie | |
dc.date.accessioned | 2020-08-22T17:31:23Z | |
dc.date.available | 2013-07-29 | |
dc.date.issued | 2013-07-29 | |
dc.identifier.uri | https://etd.library.vanderbilt.edu/etd-07172013-085324 | |
dc.identifier.uri | http://hdl.handle.net/1803/13115 | |
dc.description.abstract | Malaria is a disease caused by the parasite Plasmodium falciparum which kills 1-2.7 million people per year. Parasite resistance to widely available anti-malarial treatments such as Chloriquine is spreading rapidly, and current treatments for Chloroquine-resistant parasites tend to be unaffordable for people in the impoverished areas where malaria is endemic. Therefore, there is an increasing need for anti-malarial treatments that are easy to develop, effective, and inexpensive. In this study, we explore a novel source of anti-malarial probes by screening extracts from a library of cave actinomycetes. Using the â-hematin formation assay optimized in the Wright lab to screen for anti-malarial activity, coupled with LC-MS and 2D NMR techniques, we can isolate active compounds and determine their structure. In this project we identify the soy isoflavone Genistein as an active anti-malaria probe, and explores a new natural product resource that may be helpful in the continuing search for novel anti-malarial treatments. | |
dc.format.mimetype | application/pdf | |
dc.subject | Malaria | |
dc.subject | drug discovery | |
dc.subject | natural products | |
dc.subject | actinomycete library | |
dc.title | Isolation and Characterization of Anti-malarial Compounds from a Natural Product Library | |
dc.type | thesis | |
dc.contributor.committeeMember | Brian Bachmann | |
dc.type.material | text | |
thesis.degree.name | MS | |
thesis.degree.level | thesis | |
thesis.degree.discipline | Chemistry | |
thesis.degree.grantor | Vanderbilt University | |
local.embargo.terms | 2013-07-29 | |
local.embargo.lift | 2013-07-29 | |
dc.contributor.committeeChair | David Wright |
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