dc.creator | Hariri, Ghazal | |
dc.date.accessioned | 2020-08-22T00:22:06Z | |
dc.date.available | 2008-04-14 | |
dc.date.issued | 2007-04-14 | |
dc.identifier.uri | https://etd.library.vanderbilt.edu/etd-04022007-233352 | |
dc.identifier.uri | http://hdl.handle.net/1803/11926 | |
dc.description.abstract | The objective of this study was to image tumor-targeting using a single chain fragment variable antibody to radiation-induced P-selectin in a heterotopic Lewis lung carcinoma model by near-infrared fluorescence imaging and gamma camera imaging. In our in vitro studies, we observed antibody binding to P-selectin in endothelial cells treated with radiation. In our in vivo optical imaging study, it was observed that significant tumor-specific binding was observed in irradiated tumors expressing P-selectin as compared to unirradiated tumors. Gamma camera imaging also showed successful targeting to P-selectin in irradiated tumors with tumor binding lasting for up to 10 days post-injection. Therefore, radiation-induced P-selectin is a feasible target for the tumor-specific delivery of therapeutic drugs and radionuclides in vivo. | |
dc.format.mimetype | application/pdf | |
dc.subject | radiation therapy | |
dc.subject | P-selectin | |
dc.subject | tumor imaging | |
dc.subject | Drug targeting | |
dc.title | Radiation-Guided P-selectin Targeted Tumor Imaging in a Lung Tumor Model | |
dc.type | thesis | |
dc.contributor.committeeMember | Todd D. Giorgio | |
dc.type.material | text | |
thesis.degree.name | MS | |
thesis.degree.level | thesis | |
thesis.degree.discipline | Biomedical Engineering | |
thesis.degree.grantor | Vanderbilt University | |
local.embargo.terms | 2008-04-14 | |
local.embargo.lift | 2008-04-14 | |
dc.contributor.committeeChair | Dennis E. Hallahan | |