dc.creator | Perry-Hauser, Nicole Anna | |
dc.date.accessioned | 2020-08-21T21:08:13Z | |
dc.date.available | 2021-03-11 | |
dc.date.issued | 2019-03-11 | |
dc.identifier.uri | https://etd.library.vanderbilt.edu/etd-03112019-120219 | |
dc.identifier.uri | http://hdl.handle.net/1803/10734 | |
dc.description.abstract | The four vertebrate arrestins comprise a family of proteins that are responsible for the desensitization and internalization of over 800 subtypes of G protein-coupled receptors (GPCRs). The arrestins also serve as independent signal transducers in both a receptor-dependent and receptor-independent fashion. The nonvisual arrestins (arrestin-2 and arrestin-3, or β-arrestin-1 and β-arrestin-2) have been shown to interact with >100 signaling and trafficking proteins. In particular, the arrestins are well-characterized for their role in the scaffolding of several mitogen-activated protein kinase (MAPK) cascades. Over the course of my thesis work, I investigated the mechanisms underlying arrestin-mediated scaffolding and activation of these cascades with a specific focus on the JNK3 and ERK2 cascades. | |
dc.format.mimetype | application/pdf | |
dc.subject | signaling | |
dc.subject | scaffold | |
dc.subject | mitogen-activated protein kinase cascades | |
dc.subject | G protein-coupled receptors | |
dc.subject | arrestin | |
dc.title | Arrestins: multifunctional regulators of signaling pathways | |
dc.type | dissertation | |
dc.contributor.committeeMember | Dr. Raymond Blind | |
dc.contributor.committeeMember | Dr. Annette G. Beck-Sickinger | |
dc.contributor.committeeMember | Dr. Tina M. Iverson | |
dc.contributor.committeeMember | Dr. Vsevolod V. Gurevich | |
dc.type.material | text | |
thesis.degree.name | PHD | |
thesis.degree.level | dissertation | |
thesis.degree.discipline | Pharmacology | |
thesis.degree.grantor | Vanderbilt University | |
local.embargo.terms | 2021-03-11 | |
local.embargo.lift | 2021-03-11 | |
dc.contributor.committeeChair | Dr. Benjamin Spiller | |