dc.creator | Sparks, Erin Elizabeth | |
dc.date.accessioned | 2020-08-21T21:07:31Z | |
dc.date.available | 2013-03-14 | |
dc.date.issued | 2011-03-14 | |
dc.identifier.uri | https://etd.library.vanderbilt.edu/etd-03102011-141048 | |
dc.identifier.uri | http://hdl.handle.net/1803/10720 | |
dc.description.abstract | Cholangiopathies, or diseases which affect the biliary epithelial cells of the liver, are an important health concern in the United States. Specifically, the diagnosis of a cholangiopathy is the number one indicator of pediatric liver transplant and the number three indicator for adults. A common clinical finding in cholangiopathies is cholestasis or reduced bile flow, however the specific pathogenesis of most cholangiopathies is largely unknown.
A subtype of cholangiopathy, which this research focuses on, is the genetic cholangiopathy. One specific example of a genetic cholangiopathy is Alagille syndrome, a pleiotropic disorder primary characterized by a lack of bile ducts. Alagille syndrome is highly associated with mutations in the Notch signaling pathway. In this dissertation, I use mouse models that modulate Notch signaling to define the developmental and post-natal mechanism of cholestasis in a cholangiopathy model. | |
dc.format.mimetype | application/pdf | |
dc.subject | Cholangiopathies | |
dc.subject | Alagille | |
dc.subject | Resin Casting | |
dc.subject | Mouse Models | |
dc.title | Notch Signaling is Essential to Modulate Intrahepatic Bile Duct Structure | |
dc.type | dissertation | |
dc.contributor.committeeMember | Kathleen Gould | |
dc.contributor.committeeMember | Mark Magnuson | |
dc.contributor.committeeMember | Guoqiang Gu | |
dc.contributor.committeeMember | Stacey Huppert | |
dc.type.material | text | |
thesis.degree.name | PHD | |
thesis.degree.level | dissertation | |
thesis.degree.discipline | Cell and Developmental Biology | |
thesis.degree.grantor | Vanderbilt University | |
local.embargo.terms | 2013-03-14 | |
local.embargo.lift | 2013-03-14 | |
dc.contributor.committeeChair | James Goldenring | |