dc.contributor.author | Uzhachenko, Roman, V. | |
dc.contributor.author | Shanker, Anil | |
dc.date.accessioned | 2020-07-16T15:28:55Z | |
dc.date.available | 2020-07-16T15:28:55Z | |
dc.date.issued | 2019-08-13 | |
dc.identifier.citation | Uzhachenko RV and Shanker A (2019) CD8+ T Lymphocyte and NK Cell Network: Circuitry in the Cytotoxic Domain of Immunity. Front. Immunol. 10:1906. doi: 10.3389/fimmu.2019.01906 | en_US |
dc.identifier.issn | 1664-3224 | |
dc.identifier.uri | http://hdl.handle.net/1803/10201 | |
dc.description.abstract | Multiple effector layers in the immune system ensure an optimal temporal and spatial distribution of immune defense. Cytotoxic innate lymphoid natural killers (NK) and adaptive CD8(+) T lymphocytes (CTL) interact to elicit specific cytolytic outcomes. The CTL carry antigen-specific T cell receptors (TCR) to recognize cognate peptides bound with major histocompatibility complex class-I (MHC-I) or human leukocyte antigen (HLA) molecules on target cells. Upon TCR engagement with MHC-I:peptide at a threshold of avidity, T cell intracellular programs converge into cytolytic activity. By contrast, NK cells lack antigen-specific receptors but express a repertoire of highly polymorphic and polygenic inhibitory and activating receptors that bind various ligands including MHC and like molecules. A highly calibrated maturation enables NK cells to eliminate target cells with lowered or absent MHC-I or induced MHC-I-related molecules while maintaining their tolerance toward self-MHC. Both CTL and mature NK cells undergo membranous reorganization and express various effector molecules to eliminate aberrant cells undergoing a stress of transformation, infection or other pathological noxa. Here, we present the cellular modules that underlie the CTL-NK circuitry to maximize their effector cooperativity against stressed or cancerous cells. | en_US |
dc.description.sponsorship | This work was supported by funds to AS by the following NIH grants: U54 CA163069, U54MD007593, SC1CA182843, and R01 CA175370. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. There was no role of the funding bodies in the design or writing of the manuscript. No writing assistance was utilized in the production of this manuscript. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Frontiers in Immunology | en_US |
dc.rights | Copyright © 2019 Uzhachenko and Shanker. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | |
dc.source.uri | https://www.frontiersin.org/articles/10.3389/fimmu.2019.01906/full#h11 | |
dc.subject | CD8T cells (CTL) | en_US |
dc.subject | natural killer cells (NK) | en_US |
dc.subject | lymphocyte crosstalk | en_US |
dc.subject | immune networks | en_US |
dc.subject | cytolytic function | en_US |
dc.subject | effector cooperativity | en_US |
dc.subject | cancer | en_US |
dc.subject | immunotherapy | en_US |
dc.title | CD8(+) T Lymphocyte and NK Cell Network: Circuitry in the Cytotoxic Domain of Immunity | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.3389/fimmu.2019.01906 | |