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Now showing items 11-19 of 19
Engineering Porous Silicon Nanoparticles for Delivery of Peptide Nucleic Acid Therapeutics
(2017-03-31)
Researchers discovered the existence of non-coding RNA while unraveling the secrets of the human genome. Non-coding RNA molecules are never translated into proteins, yet they are highly abundant and serve critical functions ...
Development of pH-responsive nano-polyplexes for intracellular delivery of therapeutic biomacromolecules
(2015-04-05)
Peptide-based therapeutics hold significant therapeutic potential for use in a variety of clinical applications ranging from cancer to cardiovascular disease. However, the potential of peptide-based therapeutics is limited ...
Interactions of Gold Plasmons and Vanadium Dioxide
(2017-03-28)
The focus of this dissertation is the interaction of gold (Au) plasmonic structures and the phase change material vanadium dioxide (VO2). Vanadium dioxide modifies the local surface plasmon resonance of an Au nanoparticles ...
Mechanism of Enhanced Cellular Uptake and Cytosolic Retention of MK2 Inhibitory Peptide Nano-polyplexes
(2016-04-11)
Electrostatic complexation of a cationic MAPKAP kinase 2 inhibitory (MK2i) peptide with the anionic, pH-responsive polymer poly(propylacrylic acid) (PPAA) yields MK2i nano-polyplexes (MK2i-NPs) that significantly increase ...
Development of Drug Delivery Vehicles for Biomedical Applications
(2017-07-20)
Polymeric nanoparticles have historically been shown to be valuable tools for the solubilization and delivery of small molecule hydrophobic drugs. However, most systems do not address obstacles associated with off-target ...
Plasmonic Interactions in Gold::Vanadium Dioxide Hybrid Nanostructures
(2011-04-19)
Hybrid nanocomposites consisting of arrays of gold (Au) nanoparticles (NPs) and vanadium dioxide (VO<sub>2</sub>) were fabricated on indium-tin-oxide coated glass substrates. The Au NPs, with radii from 100 to 180nm and ...
Bioanalytical Approaches to Chemical Biology
(2010-06-01)
As the field of chemical biology evolves, so does the development of novel bioanalytical techniques capable of accurately measuring biochemical composition and regulation. This dissertation explores three aspects of ...
Delivery of CRISPR/Cas9 Ribonucleoprotein using Carrier-Free Protein Engineering or Porous Silicon Nanoparticles
(2023-07-14)
Gene editing unlocks the source code of life—DNA—for human engineering. This could enable treating myriad diseases, with huge academic and industrial efforts ongoing towards treatments for numerous cancers, neurodegenerative ...
Engineering Nanoparticle Vaccines for Respiratory Infections
(2020-06-12)
Tissue-resident memory T cells (TRM) patrol non-lymphoid organs and provide superior protection against pathogens that commonly infect mucosal and barrier tissues, such as the lungs, intestine, liver, and skin. At these ...