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Development of pH-responsive nano-polyplexes for intracellular delivery of therapeutic biomacromolecules
(2015-04-05)
Peptide-based therapeutics hold significant therapeutic potential for use in a variety of clinical applications ranging from cancer to cardiovascular disease. However, the potential of peptide-based therapeutics is limited ...
Interactions of Gold Plasmons and Vanadium Dioxide
(2017-03-28)
The focus of this dissertation is the interaction of gold (Au) plasmonic structures and the phase change material vanadium dioxide (VO2). Vanadium dioxide modifies the local surface plasmon resonance of an Au nanoparticles ...
Mechanism of Enhanced Cellular Uptake and Cytosolic Retention of MK2 Inhibitory Peptide Nano-polyplexes
(2016-04-11)
Electrostatic complexation of a cationic MAPKAP kinase 2 inhibitory (MK2i) peptide with the anionic, pH-responsive polymer poly(propylacrylic acid) (PPAA) yields MK2i nano-polyplexes (MK2i-NPs) that significantly increase ...
Rational Ligand Design for Charge Transfer in Quantum Dots
(2018-09-24)
Solar energy stands out as an extremely promising candidate to meet the need for renewable energy due to its abundance in availability and the capability of application in multiple scenarios. This work aims to push the ...
Plasmonic Interactions in Gold::Vanadium Dioxide Hybrid Nanostructures
(2011-04-19)
Hybrid nanocomposites consisting of arrays of gold (Au) nanoparticles (NPs) and vanadium dioxide (VO<sub>2</sub>) were fabricated on indium-tin-oxide coated glass substrates. The Au NPs, with radii from 100 to 180nm and ...
Bioanalytical Approaches to Chemical Biology
(2010-06-01)
As the field of chemical biology evolves, so does the development of novel bioanalytical techniques capable of accurately measuring biochemical composition and regulation. This dissertation explores three aspects of ...
Engineering Porous Silicon Nanoparticles for Delivery of Peptide Nucleic Acid Therapeutics
(2017-03-31)
Researchers discovered the existence of non-coding RNA while unraveling the secrets of the human genome. Non-coding RNA molecules are never translated into proteins, yet they are highly abundant and serve critical functions ...
Hybrid phase-changing nanostructures: from reconfigurable plasmonic devices to ultrafast dynamics
(2012-12-20)
Ultrafast photoinduced phase transitions in quantum materials could revolutionize data-storage and telecommunications technologies by modulating transport in integrated nanocircuits at terahertz speeds. In phase-changing ...
Complex plasmonic behavior in archimedean nanospirals
(2011-12-10)
This work explores the complex plasmonic phenomena generated by Archimedean nanospirals. Arrays of gold nanospirals are fabricated with varying arm spacings and arm widths, as well as winding numbers ranging from 2 to 4π, ...
Low-resource diagnostic assay based on disruption of radial flow in an evaporating drop
(2010-12-16)
More than 700,000 deaths are attributed to malarial infection annually in the rural areas of Sub-Saharan Africa. Effective and reliable early detection is inadequate with currently available technology. Development of a ...