Multi-exponential T2 Myelin Water Imaging in Ex-Vivo Rodent Brain at 7T and 15.2T

dc.contributor.committeeChair	Mark D. Does
dc.contributor.committeeMember	Daniel F. Gochberg
dc.creator	West, Kathryn Louise
dc.date.accessioned	2020-08-21T21:34:33Z
dc.date.available	2016-04-16
dc.date.issued	2014-04-16
dc.description.abstract	To apply MWI techniques to excised, fixed rodent brains, multi-exponential T2 (MET2) data were acquired at high (7T) and ultra-high (15.2T) fields with and without tissue doping with Gadolinium to increase SNR efficiency. From relaxivity measurements, optimal scan parameters are found based on the minimal Cramér-Rao lower bounds (CRLB) of variance of myelin water fraction (MWF). Subsequently acquired MET2 data were analyzed to obtain myelin water fraction (MWF) maps with and without contrast agent at each field strength with various techniques, displaying the potential for MWI in rodent brain in the study of myelin content across whole brain.
dc.format.mimetype	application/pdf
dc.identifier.uri	https://etd.library.vanderbilt.edu/etd-03252014-084553
dc.identifier.uri	http://hdl.handle.net/1803/11313
dc.subject	ultra-high field
dc.subject	Muliti-exponential T2
dc.subject	Myelin
dc.title	Multi-exponential T2 Myelin Water Imaging in Ex-Vivo Rodent Brain at 7T and 15.2T
dc.type	thesis
dc.type.material	text
local.embargo.lift	2016-04-16
local.embargo.terms	2016-04-16
thesis.degree.discipline	Biomedical Engineering
thesis.degree.grantor	Vanderbilt University
thesis.degree.level	thesis
thesis.degree.name	MS

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