HOST CHARACTERISTICS ASSOCIATED WITH BLEEDING FOLLOWING PERCUTANEOUS TRANSTHORACIC NEEDLE BIOPSIES PERFORMED ON POTENTIALLY CANCEROUS LESIONS

Abstract

Introduction: Thoracic lesions are most frequently diagnosed with a percutaneous transthoracic needle biopsy (PTNB) with procedure risks of hemoptysis and hemothorax. This study aimed to describe patient and procedure characteristics associated with bleeding, hemoptysis requiring intervention, and hemothorax requiring intervention. Methods: Investigators used a retrospective, case-control design of 407patients with bleeding following PTNB between January 2010 and December 2021 and 407matched controls. Matching variables included sex, oncologic diagnosis, and procedure date. Associations of characteristics associated with the outcomes of interest were tested using multiple logistic regressions (bleeding, hemoptysis requiring intervention) And binary logistic regressions (hemothorax requiring intervention). Results: Platelet counts between 50-99x103/ul, diastolic blood pressure (DBP) over 70mmHg, systolic blood pressure under 140 mmHg, history of lung resection, larger diameter needle use (18-gauge), and supine positioning were associated with increased likelihood of bleeding while smoking and having a pleural biopsy was associated with a decreased likelihood of bleeding (p < .05).). Compared to matched controls, patients with hemoptysis, were older, had a higher body mass index, higher DBP, and lower SBP (p < .05). ). Longer pre-procedure partial thromboplastin time, 18-gauge biopsy needle use, and not taking aspirin was associated with hemothorax requiring intervention (p < .05). Conclusion: This study was among the first to explore characteristics associated with bleeding following PTNB using a case-control design. Results lay the foundation to develop a future risk assessment tool.