dc.contributor.author | Amimo, Floriano | |
dc.contributor.author | Moon, Troy D. | |
dc.contributor.author | Magit, Anthony | |
dc.contributor.author | Sacarlal, Jahit | |
dc.contributor.author | Lambert, Ben | |
dc.contributor.author | Nomura, Shuhei | |
dc.date.accessioned | 2020-04-24T20:41:49Z | |
dc.date.available | 2020-04-24T20:41:49Z | |
dc.date.issued | 2019-06 | |
dc.identifier.citation | Amimo F, Moon TD, Magit A, et al Trends in comparative efficacy and safety of malaria control interventions for maternal and child health outcomes in Africa: a study protocol for a Bayesian network meta-regression exploring the effect of HIV and malaria endemicity spectrum BMJ Open 2019;9:e024313. doi: 10.1136/bmjopen-2018-024313 | en_US |
dc.identifier.issn | 2044-6055 | |
dc.identifier.uri | http://hdl.handle.net/1803/9955 | |
dc.description.abstract | Methods We will review all randomised controlled trials that investigated malaria control interventions in pregnant women in sub-Saharan Africa and were published between January 1980 and December 2018. We will subsequently use network meta-regression to estimate temporal trends in the relative and absolute efficacy and safety of Intermittent Preventive Treatments, Intermittent Screening and Treatments, Insecticide-treated bed nets, and their combinations, and predict their ranking according to their relative and absolute efficacy and safety over time. Our outcomes will include 12 maternal and 7 child mortality and morbidity outcomes, known to be associated with either malaria infection or control. We will use intention-to-treat analysis to derive our estimates and meta-regression to estimate temporal trends and the effect modification by HIV infection, malaria endemicity and Plasmodium falciparum resistance to sulfadoxine-pyrimethamine, while adjusting for multiple potential confounders via propensity score calibration. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | BMJ OPEN | en_US |
dc.rights | This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. | |
dc.source.uri | https://bmjopen.bmj.com/content/bmjopen/9/2/e024313.full.pdf | |
dc.subject | INTERMITTENT PREVENTIVE TREATMENT | en_US |
dc.subject | SULFADOXINE-PYRIMETHAMINE RESISTANCE | en_US |
dc.subject | RANDOMIZED CONTROLLED-TRIALS | en_US |
dc.subject | PLASMODIUM-FALCIPARUM | en_US |
dc.subject | UNSTABLE TRANSMISSION | en_US |
dc.subject | DIHYDROARTEMISININ-PIPERAQUINE | en_US |
dc.subject | NEONATAL-MORTALITY | en_US |
dc.subject | PROPENSITY SCORE | en_US |
dc.subject | BIRTH-WEIGHT | en_US |
dc.subject | PREGNANCY | en_US |
dc.title | Trends in comparative efficacy and safety of malaria control interventions for maternal and child health outcomes in Africa: a study protocol for a Bayesian network meta-regression exploring the effect of HIV and malaria endemicity spectrum | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1136/bmjopen-2018-024313 | |