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Nutritional Heterogeneity Among Aspergillus fumigatus Strains Has Consequences for Virulence in a Strain- and Host-Dependent Manner
(FRONTIERS IN MICROBIOLOGY, 2019-04-24)
Acquisition and subsequent metabolism of different carbon and nitrogen sources have been shown to play an important role in virulence attributes of the fungal pathogen Aspergillus fumigatus, such as the secretion of host ...
Chemical Control of Mosquitoes and the Pesticide Treadmill: A Case for Photosensitive Insecticides as Larvicides
(Insects, 2022-11-28)
Simple Summary Mosquitoes transmit disease, and over the past century, mosquito control has mostly relied on chemical insecticides that target the adult life stage. We review methods of mosquito control and argue that ...
Clinical characteristics and electrophysiologic properties of SCN5A variants in fever-induced Brugada syndrome
(Ebiomedicine, 2022-12)
Background Brugada syndrome (BrS) is a severe inherited arrhythmia syndrome that can be unmasked by fever.Methods A multicentre clinical analysis was performed in 261 patients diagnosed with fever-induced BrS, including ...
Large protein organelles form a new iron sequestration system with high storage capacity
(eLife, 2019-07-08)
Iron storage proteins are essential for cellular iron homeostasis and redox balance. Ferritin proteins are the major storage units for bioavailable forms of iron. Some organisms lack ferritins, and it is not known how they ...
Species-level Repertoire Size Predicts a Correlation Between Individual Song Elaboration and Reproductive Success
(ECOLOGY AND EVOLUTION, 2019-07)
Birdsong has long been considered a sexually selected trait that relays honest information about male quality, and laboratory studies generally suggest that female songbirds prefer larger repertoires. However, analysis of ...
The Wolbachia Mobilome in Culex Pipiens Includes a Putative Plasmid (vol 10, 1050, 2019)
(NATURE COMMUNICATIONS, 2019-07-12)
Wolbachia is a genus of obligate intracellular bacteria found in nematodes and arthropods worldwide, including insect vectors that transmit dengue, West Nile, and Zika viruses. Wolbachia's unique ability to alter host ...
The Astonishing Behavior of Electric Eels
(Frontiers in Integrative Neuroscience, 2019-07-16)
The remarkable physiology of the electric eel (Electrophorus electricus) made it one of the first model species in science. It was pivotal for understanding animal electricity in the 1700s, was investigated by Humboldt and ...
Efficacy of virtual and asynchronous teaching of computer-assisted diagnosis of genetic diseases seen in clinics
(Wiley, 2021-12-11)
We studied if clinicians could gain sufficient working knowledge of a computer-assisted diagnostic decision support system (DDSS) (SimulConsult), to make differential diagnoses (DDx) of genetic disorders. We hypothesized ...
Mitofusins Mfn1 and Mfn2 Are Required to Preserve Glucose- but Not Incretin-Stimulated beta-Cell Connectivity and Insulin Secretion
(Diabetes, 2022-07)
Mitochondrial glucose metabolism is essential for stimulated insulin release from pancreatic beta-cells. Whether mitofusin gene expression, and hence, mitochondrial network integrity, is important for glucose or incretin ...
Application of a Human Blood Brain Barrier Organ-on-a-Chip Model to Evaluate Small Molecule Effectiveness against Venezuelan Equine Encephalitis Virus
(Viruses-basel, 2022-12-15)
The blood brain barrier (BBB) is a multicellular microenvironment that plays an important role in regulating bidirectional transport to and from the central nervous system (CNS). Infections by many acutely infectious viruses ...