Browsing Division of Hematology / Oncology by Author "Savona, Michael R."
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Sampathi, Shilpa; Acharya, Pankaj; Zhao, Yue; Wang, Jing; Stengel, Kristy; Liu, Qi; Savona, Michael R.; Hiebert, Scott W. (NUCLEIC ACIDS RESEARCH, 2019-05)The t(8;21) is one of the most frequent chromosomal translocations associated with acute myeloid leukemia (AML). We found that t(8; 21) AML were extremely sensitive to THZ1, which triggered apoptosis after only 4 h. We ...
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Savona, Michael R.; Seegmiller, Adam (LEUKEMIA, 2019-07)Risk stratification is critical in the care of patients with myelodysplastic syndromes (MDS). Approximately 10% have a complex karyotype (CK), defined as more than two cytogenetic abnormalities, which is a highly adverse ...