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CpG-related SNPs in the MS4A region have a dose-dependent effect on risk of late-onset Alzheimer disease
(Aging Cell, 2019-08)
CpG-related single nucleotide polymorphisms (CGS) have the potential to perturb DNA methylation; however, their effects on Alzheimer disease (AD) risk have not been evaluated systematically. We conducted a genome-wide ...
Deletion of Tet proteins results in quantitative disparities during ESC differentiation partially attributable to alterations in gene expression
(BMC Developmental Biology, 2019-07-08)
BackgroundThe Tet protein family (Tet1, Tet2, and Tet3) regulate DNA methylation through conversion of 5-methylcytosine to 5-hydroxymethylcytosine which can ultimately result in DNA demethylation and play a critical role ...