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Inhibition of MYC by the SMARCB1 tumor suppressor
(Nature Communications, 2019-05-01)
SMARCB1 encodes the SNF5 subunit of the SWI/SNF chromatin remodeler. SNF5 also interacts with the oncoprotein transcription factor MYC and is proposed to stimulate MYC activity. The concept that SNF5 is a coactivator for ...
Identification of drug-specific public TCR driving severe cutaneous adverse reactions
(Nature Communications, 2019-08-08)
Drug hypersensitivity such as severe cutaneous adverse reactions (SCAR), including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), could be life-threatening. Here, we enroll SCAR patients to investigate ...