Browsing School of Medicine by Subject "beta-Cell differentiation"
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Point mutations in the PDX1 transactivation domain impair human beta-cell development and function (Molecular Metabolism, 2019-06)Objective: Hundreds of missense mutations in the coding region of PDX1 exist; however, if these mutations predispose to diabetes mellitus is unknown. Methods: In this study, we screened a large cohort of subjects with ...