Browsing School of Medicine by Subject "ACTIVATION"

Now showing items 1-2 of 2

    • Identification of drug-specific public TCR driving severe cutaneous adverse reactions 
      Phillips, Elizabeth Jane; Mallal, Simon Alexander (Nature Communications, 2019-08-08)
      Drug hypersensitivity such as severe cutaneous adverse reactions (SCAR), including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), could be life-threatening. Here, we enroll SCAR patients to investigate ...
    • Inhibition of MYC by the SMARCB1 tumor suppressor 
      Weissmiller, April M.; Wang, Jing; Lorey, Shelly L.; Howard, Gregory C.; Martinez, Ernest; Liu, Qi; Tansey, William P. (Nature Communications, 2019-05-01)
      SMARCB1 encodes the SNF5 subunit of the SWI/SNF chromatin remodeler. SNF5 also interacts with the oncoprotein transcription factor MYC and is proposed to stimulate MYC activity. The concept that SNF5 is a coactivator for ...