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Patient Registries in Idiopathic Pulmonary Fibrosis
(American Journal of Respiratory and Critical Care Medicine, 2019-07-15)
Over the past decade, several large registries of patients with idiopathic pulmonary fibrosis (IPF) have been established. These registries are collecting a wealth of longitudinal data on thousands of patients with this ...
Oral Tresprostinil in Transition or as Add-on Therapy in Pediatric Pulmonary Arterial hypertension
(Pulmonary Circulation, 2019-07-12)
Treprostinil, a prostacyclin analogue, is approved for the treatment of pulmonary arterial hypertension (PAH) in adults. Transition from parenteral to oral treprostinil has been successfully accomplished in adults with PAH ...
Defects in COG-Mediated Golgi Trafficking Alter Endo-Lysosoma System in Human Cells
(FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2019-07-03)
The conserved oligomeric complex (COG) is a multi-subunit vesicle tethering complex that functions in retrograde trafficking at the Golgi. We have previously demonstrated that the formation of enlarged endo-lysosomal ...
Defects in COG-Mediated Golgi Trafficking Alter Endo-Lysosoma System in Human Cells
(FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2019-07-03)
The conserved oligomeric complex (COG) is a multi-subunit vesicle tethering complex that functions in retrograde trafficking at the Golgi. We have previously demonstrated that the formation of enlarged endo-lysosomal ...
Defects in COG-Mediated Golgi Trafficking Alter Endo-Lysosoma System in Human Cells
(FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2019-07-03)
The conserved oligomeric complex (COG) is a multi-subunit vesicle tethering complex that functions in retrograde trafficking at the Golgi. We have previously demonstrated that the formation of enlarged endo-lysosomal ...
Pirfenidone Treatment in Individuals with Idiopathic Pulmonary Fibrosis: Impact of Timing of Treatment Initiation
(Annals of the American Thoracic Society, 2019-07)
To the Editor:
Idiopathic pulmonary fibrosis (IPF) is a debilitating, progressive, fatal, fibrosing lung disease (1, 2). Pirfenidone and nintedanib are oral antifibrotics with demonstrated efficacy in reducing lung ...
The Children's Respiratory and Environmental Workgroup (CREW) birth cohort consortium: design, methods, and study population
(Respiratory Reserarch, 2019-06-10)
BackgroundSingle birth cohort studies have been the basis for many discoveries about early life risk factors for childhood asthma but are limited in scope by sample size and characteristics of the local environment and ...
Increased monocyte count as a cellular biomarker for poor outcomes in fibrotic diseases: a retrospective, multicentre cohort study
(Lancet Respiratory Medicine, 2019-06)
Background There is an urgent need for biomarkers to better stratify patients with idiopathic pulmonary fibrosis by risk for lung transplantation allocation who have the same clinical presentation. We aimed to investigate ...
Identifying Patients with Pulmonary Arterial Hypertension Using Administrative Claims Algorithms
(Annals of the American Thoracic Society, 2019-07)
Retrospective administrative claims database studies provide real-world evidence about treatment patterns, healthcare resource use, and costs for patients and are increasingly used to inform policy-making, drug formulary, ...
Preparation and Identification of ACE Inhibitory Peptides from the Marine Macroalga Ulva intestinalis
(Marine Druges, 2019-03)
Angiotensin I-converting enzyme (ACE) inhibitory peptides derived from seaweed represent a potential source of new antihypertensive. The aim of this study was to isolate and purify ACE inhibitory peptides (ACEIPs) from the ...