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    Autologous Chondrocyte Grafting Promotes Bone Formation in the Posterolateral Spine

    Sielatycki, J. Alex
    Saito, Masanori
    Yuasa, Masato
    Moore-Lotridge, Stephanie N.
    Uppuganti, Sasidhar
    Colazo, Juan M.
    Hysong, Alexander A.
    Robinette, J. Patton
    Okawa, Atsushi
    Yoshii, Toshitaka
    Schwartz, Herbert S.
    Nyman, Jeffry S.
    Schoenecker, Jonathan G.
    : http://hdl.handle.net/1803/9373
    : 2018-03-23

    Abstract

    Pseudarthrosis following spinal fusion remains problematic despite modern surgical and grafting techniques. In surgical spinal fusion, new bone forms via intramembranous and endochondral ossification, with endochondral ossification occurring in the hypoxic zones of the fusion bed. During bone development and fracture healing, the key cellular mediator of endochondral ossification is the hypertrophic chondrocyte given its ability to function in hypoxia and induce neovascularization and ossification. We therefore hypothesize that hypertrophic chondrocytes may be an effective bone graft alternative.
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