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Integrative genomic analyses of APOBEC-mutational signature, expression and germline deletion of APOBEC3 genes, and immunogenicity in multiple cancer types
(BMC Medical Genomics, 2019-09-18)
Background Although APOBEC-mutational signature is found in tumor tissues of multiple cancers, how a common germline APOBEC3A/B deletion affects the mutational signature remains unclear. Methods Using data from 10 cancer ...
The genetic interplay between body mass index, breast size and breast cancer risk: a Mendelian randomization analysis
(International Journal of Epidemiology, 2019-06)
Background: Evidence linking breast size to breast cancer risk has been inconsistent, and its interpretation is often hampered by confounding factors such as body mass index (BMI). Here, we used linkage disequilibrium score ...
Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions
(AMERICAN JOURNAL OF EPIDEMIOLOGY, 2019-06)
A person's lipid profile is influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures has not been studied. We therefore incorporated gene-alcohol interactions ...
Association of Diabetes With All-Cause and Cause-Specific Mortality in Asia A Pooled Analysis of More Than 1 Million Participants
(JAMA Network Open, 2019-04)
IMPORTANCE Asia is home to the largest diabetic populations in the world. However, limited studies have quantified the association of diabetes with all-cause and cause-specific mortality in Asian populations.
OBJECTIVES ...
The functional ALDH2 polymorphism is associated with breast cancer risk: A pooled analysis from the Breast Cancer Association Consortium
(Molecular Genetics & Genome Medicine, 2019-06)
BackgroundEpidemiological studies consistently indicate that alcohol consumption is an independent risk factor for female breast cancer (BC). Although the aldehyde dehydrogenase 2 (ALDH2) polymorphism (rs671: Glu>Lys) has ...
The Consortium of Metabolomics Studies (COMETS): Metabolomics in 47 Prospective Cohort Studies
(AMERICAN JOURNAL OF EPIDEMIOLOGY, 2019-06)
The Consortium of Metabolomics Studies (COMETS) was established in 2014 to facilitate large-scale collaborative research on the human metabolome and its relationship with disease etiology, diagnosis, and prognosis. COMETS ...