Browsing Vanderbilt University Medical Center by Title
Now showing items 251-270 of 315
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(Annals of Oncology, 2020-02)Background: The addition of atezolizumab to carboplatin and etoposide (CP/ET) significantly improved progression-free and overall survival for patients with extensive-stage small-cell lung cancer (ES-SCLC) in the IMpower133 ...
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(BMJ Open Respiratory Research, 2019-02)Introduction Nintedanib slows disease progression in patients with idiopathic pulmonary fibrosis (IPF) by reducing the rate of decline in forced vital capacity, with an adverse event profile that is manageable for most ...
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(BMC Pharmacology & Toxicology, 2020-01-06)Background 2-Hydroxybenzylamine (2-HOBA) is a selective dicarbonyl electrophile scavenger being developed as a nutritional supplement to help protect against the development of conditions associated with dicarbonyl ...
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(BMC Medical Genetics, 2020-02-14)Background Epigenetics could facilitate greater understanding of disparities in the emergence of childhood obesity. While blood is a common tissue used in human epigenetic studies, saliva is a promising tissue. Our prior ...
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(Clinical and Translational Gastroenterology, 2019-05-20)OBJECTIVES: Eosinophilic esophagitis (EoE) is an allergen-mediated inflammatory disease affecting the esophagus. Although microbial communities may affect the host immune responses, little is known about the role of the ...
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(Molecular Metabolism, 2023-01-13)Objective: Oxidative stress contributes to the development of insulin resistance (IR) and atherosclerosis. Peroxidation of lipids produces reactive dicarbonyls such as Isolevuglandins (IsoLG) and malondialdehyde (MDA) that ...
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(Frontiers in Human Neuroscience, 2020-01-24)Since Tulving proposed a distinction in memory between semantic and episodic memory, considerable effort has been directed towards understanding their similar and unique features. Of particular interest has been the extent ...
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(JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY, 2019-06)Background. Staphylococcus aureus is among the most commonly identified causes of invasive bacterial infection in children; however, reliable results from cultures of sterile-site samples often cannot be obtained, which ...
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(Frontiers in Neurlogy, 2020-02-04)A growing body of literature has examined sex differences in a variety of outcomes from moderate-severe traumatic brain injury (TBI), including outcomes for social functioning. Social functioning is an area in which adults ...
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(Pulmonary Circulation, 2020-01)Pulmonary arterial hypertension (PAH) is a sexually dimorphic disease that for unknown reasons affects women more than men. The role of estrogens, both endogenous and exogenous, and reproductive factors in this female ...
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(G3-GENES Genomes Genetics, 2019-08)Evolutionary changes in enhancers are widely associated with variation in human traits and diseases. However, studies comprehensively quantifying levels of selection on enhancers at multiple evolutionary periods during ...
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(2017-02-09)Background. Prior studies of pediatric musculoskeletal infection have suggested that methicillin-resistant Staphylococcus aureus (MRSA) infections result in worse outcomes compared with infections with methicillin-susceptible ...
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(Cell Death & Disease, 2023-01-16)Tumor growth, metastasis and therapeutic response are believed to be regulated by the tumor and its microenvironment (TME) in advanced renal cell carcinoma (RCC). However, the mechanisms underlying genomic, transcriptomic ...
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(Molecular Genetics & Genomic Medicine, 2019-09)Background Congenital hydrocephalus (CH) is a highly morbid disease that features enlarged brain ventricles and impaired cerebrospinal fluid homeostasis. Although early linkage or targeted sequencing studies in large ...
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(Brain Communications, 2022-12-17)Sleep is the preferential period when epileptic spike-wave discharges appear in human epileptic patients, including genetic epileptic seizures such as Dravet syndrome with multiple mutations including SCN1A mutation and ...
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(Magnetic Resonance Imaging, 2020-02)Purpose:: Magnetic resonance fingerprinting (MRF) is a state-of-the-art quantitative MRI technique with a computationally demanding reconstruction process, the accuracy of which depends on the accuracy of the signal model ...
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(Hepatology, 2019-08)Currently, the only approved hepatitis C virus (HCV) treatment for children aged <12 years is pegylated interferon plus ribavirin. In an open-label study, we evaluated the safety and efficacy of sofosbuvir plus ribavirin ...
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(Neuroimage-/Clinical, 2019)Abstract Purpose: This study aims to systematically evaluate the accuracy and precision of pool size ratio (PSR) measurements from quantitative magnetization transfer (qMT) acquisitions using simplified models in the ...
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(BMC Medica Genomics, 2020-03-06)Background Few somatic mutations have been linked to breast cancer metastasis, whereas transcriptomic differences among primary tumors correlate with incidence of metastasis, especially to the lungs and brain. However, the ...
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(BMJ Open, 2019-10)Introduction Patient-reported outcome (PRO) measures are increasingly developed with multisite, representative patient populations so that they can serve as a primary endpoint in clinical trials and longitudinal studies. ...