dc.description.abstract | Genome sequencing technology provides new and promising tests for clinical practice,
including whole genome sequencing, which measures an individual's complete DNA
sequence, and whole exome sequencing, which measures the DNA for all genes coding
for proteins. These technologies make it possible to test for multiple genes in a single test,
which increases the efficiency of genetic testing. However, they can also produce large
amounts of information that cannot be interpreted or is of limited clinical utility. This
additional information could be distracting for patients and clinicians, and contribute to
unnecessary healthcare costs. The potential for genomic sequencing to improve care will
be context-dependent, varying for different patients and clinical settings. This Article
argues that a disciplined approach is needed, incorporating research to assess when and
how genomic information can improve clinical outcomes, practice guidelines that direct
optimal uses of genomic sequencing, and efforts to limit the production of genomic
information unrelated to the clinical needs of the patient. Without this approach, genomic
testing could add to current unsustainable healthcare costs and prove unaffordable in the
long run. | en_US |