• About
    • Login
    View Item 
    •   Institutional Repository Home
    • Undergraduate Honors Research
    • Undergraduate Honors Program - Physics and Astronomy Department
    • Highest Honors in Physics
    • View Item
    •   Institutional Repository Home
    • Undergraduate Honors Research
    • Undergraduate Honors Program - Physics and Astronomy Department
    • Highest Honors in Physics
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of Institutional RepositoryCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsDepartmentThis CollectionBy Issue DateAuthorsTitlesSubjectsDepartment

    My Account

    LoginRegister

    Simulation and optimization of pulsed Chemical Exchange Saturation Transfer for clinical application at 3T

    Dewey, Blake
    : http://hdl.handle.net/1803/5229
    : 2013-04-22

    Abstract

    Chemical Exchange Saturation Transfer (CEST) is often overlooked as a method for the investigation of metabolites in vivo due to the time required to obtain a full spectrum. We investigated the feasibility and optimization of a pulsed CEST technique that interleaves an echo planer imaging (EPI) readout with saturation in order to reduce time. In addition, we incorporated a multi-shot EPI sequence that reduces distortions. To achieve this, computer simulations based on the Bloch equations were used to optimize scan parameters while keeping scan time in the clinical timeframe. To analyze the data, a number of Lorentizian fitting algorithms were investigated to evaluate their ability to isolate CEST contrast. By using a 30 ms pulse at 2 μT, we were able to achieve CEST contrast on the order of 2% and could provide APT maps based on an adapted Lorentzian fitting method. In the process of this fitting, it was also discovered that MTR contrast could also be recovered from the CEST data, allowing for MT and CEST to be acquired at the same time.
    Show full item record

    Files in this item

    Thumbnail
    Name:
    blake_thesis.pdf
    Size:
    3.762Mb
    Format:
    PDF
    View/Open

    This item appears in the following collection(s):

    • Highest Honors in Physics

    Connect with Vanderbilt Libraries

    Your Vanderbilt

    • Alumni
    • Current Students
    • Faculty & Staff
    • International Students
    • Media
    • Parents & Family
    • Prospective Students
    • Researchers
    • Sports Fans
    • Visitors & Neighbors

    Support the Jean and Alexander Heard Libraries

    Support the Library...Give Now

    Gifts to the Libraries support the learning and research needs of the entire Vanderbilt community. Learn more about giving to the Libraries.

    Become a Friend of the Libraries

    Quick Links

    • Hours
    • About
    • Employment
    • Staff Directory
    • Accessibility Services
    • Contact
    • Vanderbilt Home
    • Privacy Policy