dc.contributor.author | Lai, Yijie | |
dc.contributor.author | Dai, Lulin | |
dc.contributor.author | Wang, Tao | |
dc.contributor.author | Zhang, Yingying | |
dc.contributor.author | Zhao, Yijie | |
dc.contributor.author | Wang, Fengting | |
dc.contributor.author | Liu, Qimin | |
dc.contributor.author | Zhan, Shikun | |
dc.contributor.author | Li, Dianyou | |
dc.contributor.author | Jin, Haiyan | |
dc.contributor.author | Fang, Yiru | |
dc.contributor.author | Voon, Valerie | |
dc.contributor.author | Sun, Bomin | |
dc.date.accessioned | 2023-02-02T23:15:29Z | |
dc.date.available | 2023-02-02T23:15:29Z | |
dc.date.issued | 2022-12-30 | |
dc.identifier.citation | Lai Y, Dai L, Wang T, et al Structural and functional correlates of the response to deep brain stimulation at ventral capsule/ventral striatum region for treatment-resistant depression Journal of Neurology, Neurosurgery & Psychiatry Published Online First: 30 December 2022. doi: 10.1136/jnnp-2022-329702 | en_US |
dc.identifier.issn | 0022-3050 | |
dc.identifier.other | eISSN 1468-330X | |
dc.identifier.other | PubMed ID36585242 | |
dc.identifier.uri | http://hdl.handle.net/1803/17978 | |
dc.description.abstract | BackgroundThough deep brain stimulation (DBS) shows increasing potential in treatment-resistant depression (TRD), the underlying neural mechanisms remain unclear. Here, we investigated functional and structural connectivities related to and predictive of clinical effectiveness of DBS at ventral capsule/ventral striatum region for TRD. MethodsStimulation effects of 71 stimulation settings in 10 TRD patients were assessed. The electric fields were estimated and combined with normative functional and structural connectomes to identify connections as well as fibre tracts beneficial for outcome. We calculated stimulation-dependent optimal connectivity and constructed models to predict outcome. Leave-one-out cross-validation was used to validate the prediction value. ResultsSuccessful prediction of antidepressant effectiveness in out-of-sample patients was achieved by the optimal connectivity profiles constructed with both the functional connectivity (R=0.49 at p<10-4; deviated by 14.4 +/- 10.9% from actual, p<0.001) and structural connectivity (R=0.51 at p<10-5; deviated by 15.2 +/- 11.5% from actual, p<10-5). Frontothalamic pathways and cortical projections were delineated for optimal clinical outcome. Similarity estimates between optimal connectivity profile from one modality (functional/structural) and individual brain connectivity in the other modality (structural/functional) significantly cross-predicted the outcome of DBS. The optimal structural and functional connectivity mainly converged at the ventral and dorsal lateral prefrontal cortex and orbitofrontal cortex. ConclusionsConnectivity profiles and fibre tracts following frontothalamic streamlines appear to predict outcome of DBS for TRD. The findings shed light on the neural pathways in depression and may be used to guide both presurgical planning and postsurgical programming after further validation. | en_US |
dc.description.sponsorship | This deep brain stimulation intervention was supported by an unrestricted,
investigator-initiated research grant by Scenery Inc (Drs Sun and Li), which
provided the devices used. The project was sponsored by SJTU Trans-med Awards
Research (2019015 to Dr. Sun), Shanghai Clinical Research Centre for Mental
Health (19MC191100 to Dr. Sun) and Shanghai Municipal Science and Technology
Commission (21DZ1100303 to Dr. Sun). Dr. Sun was also sponsored by the National
Natural Science Foundation of China (81771482). Dr. Voon was supported by
the Guangci Professorship Programme of Ruijin Hospital and a Medical Research
Council Senior Clinical Fellowship (MR/P008747/1). Dr. Lai was sponsored by the
National Natural Science Foundation of China (82101546) and the Shanghai Sailing
Program (21YF1426700). The funding sources were not involved in the design and
conduct of the study; collection, management, analysis, and interpretation of the
data; preparation, review, or approval of the manuscript; and decision to submit the
manuscript for publication. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Journal of Neurology, Neurosurgery & Psychiatry | en_US |
dc.rights | © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. | |
dc.source.uri | https://jnnp.bmj.com/content/early/2022/12/30/jnnp-2022-329702 | |
dc.title | Structural and functional correlates of the response to deep brain stimulation at ventral capsule/ventral striatum region for treatment-resistant depression | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1136/jnnp-2022-329702 | |