| dc.contributor.author | Sterling, Timothy R. | |
| dc.contributor.author | Rebeiro, Peter F. | |
| dc.date.accessioned | 2021-02-18T18:30:10Z | |
| dc.date.available | 2021-02-18T18:30:10Z | |
| dc.date.issued | 2019-12 | |
| dc.identifier.citation | Althoff, K. N., Chandran, A., Zhang, J., Arevalo, W. M., Gange, S. J., Sterling, T. R., Gill, M. J., Justice, A. C., Palella, F. J., Rebeiro, P. F., Silverberg, M. J., Mayor, A. M., Horberg, M. A., Thorne, J. E., Rabkin, C. S., Mathews, W. C., Klein, M. B., Humes, E., Lee, J., Hogg, R., … North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) of IeDEA (2019). Life-Expectancy Disparities Among Adults With HIV in the United States and Canada: The Impact of a Reduction in Drug- and Alcohol-Related Deaths Using the Lives Saved Simulation Model. American journal of epidemiology, 188(12), 2097–2109. https://doi.org/10.1093/aje/kwz232 | en_US |
| dc.identifier.issn | 0002-9262 | |
| dc.identifier.issn | eISSN: 1476-6256 | |
| dc.identifier.uri | http://hdl.handle.net/1803/16424 | |
| dc.description | Only Vanderbilt University affiliated authors are listed on VUIR. For a full list of authors, access the version of record at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036649/ | en_US |
| dc.description.abstract | Improvements in life expectancy among people living with human immunodeficiency virus (PLWH) receiving antiretroviral treatment in the United States and Canada might differ among key populations. Given the difference in substance use among key populations and the current opioid epidemic, drug- and alcohol-related deaths might be contributing to the disparities in life expectancy. We sought to estimate life expectancy at age 20 years in key populations (and their comparison groups) in 3 time periods (2004-2007, 2008-2011, and 2012-2015) and the potential increase in expected life expectancy with a simulated 20% reduction in drug- and alcohol-related deaths using the novel Lives Saved Simulation model. Among 92,289 PLWH, life expectancy increased in all key populations and comparison groups from 2004-2007 to 2012-2015. Disparities in survival of approximately a decade persisted among black versus white men who have sex with men and people with (vs. without) a history of injection drug use. A 20% reduction in drug- and alcohol-related mortality would have the greatest life-expectancy benefit for black men who have sex with men, white women, and people with a history of injection drug use. Our findings suggest that preventing drug- and alcohol-related deaths among PLWH could narrow disparities in life expectancy among some key populations, but other causes of death must be addressed to further narrow the disparities. | en_US |
| dc.description.sponsorship | This work was supported by the National Institutes of Health (grants U01AI069918, F31AI124794, F31DA037788, G12MD007583, K01AI093197, K01AI131895, K23EY013707, K24AI065298, K24AI118591, K24DA000432, KL2TR000421, M01RR000052, N01CP01004, N02CP055504, N02CP91027, P30AI027757, P30AI027763, P30AI027767, P30AI036219, P30AI050410, P30AI094189, P30AI110527, P30MH62246, R01AA016893, R01CA165937, R01DA011602, R01DA012568, R01AG053100, R24AI067039, U01AA013566, U01AA020790, U01AI031834, U01AI034989, U01AI034993, U01AI034994, U01AI035004, U01AI035039, U01AI035040, U01AI035041, U01AI035042, U01AI037613, U01AI037984, U01AI038855, U01AI038858, U01AI042590, U01AI068634, U01AI068636, U01AI069432, U01AI069434, U01AI103390, U01AI103397, U01AI103401, U01AI103408, U01DA03629, U01DA036935, U01HD032632, U10EY008057, U10EY008052, U10EY008067, U24AA020794,U54MD007587, UL1RR024131, UL1TR000004, UL1TR000083, UL1TR000454, UM1AI035043, Z01CP010214, and Z01CP010176), the Centers for Disease Control and Prevention (contracts CDC-200-2006-18797 and CDC-200-2015-63931), the Agency for Healthcare Research and Quality (contract 90047713), the Health Resources and Services Administration (contract 90051652), the Canadian Institutes of Health Research (grants CBR-86906, CBR-94036, HCP-97105, and TGF-96118), the Ontario Ministry of Health and Long Term Care, and the Government of Alberta (Canada). Additional support was provided by the National Cancer Institute, National Institute of Mental Health, and National Institute on Drug Abuse, as well as the Johns Hopkins Center for AIDS Research (grant P30AI094189). | en_US |
| dc.language.iso | en_US | en_US |
| dc.publisher | American Journal of Epidemiology | en_US |
| dc.rights | Copyright © The Author(s) 2019. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com | |
| dc.source.uri | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036649/ | |
| dc.subject | black women | en_US |
| dc.subject | drug- and alcohol-related deaths | en_US |
| dc.subject | health disparities | en_US |
| dc.subject | Hispanic adults | en_US |
| dc.subject | HIV | en_US |
| dc.subject | life expectancy | en_US |
| dc.subject | men who have sex with men | en_US |
| dc.subject | people who inject drugs | en_US |
| dc.title | Life-Expectancy Disparities Among Adults With HIV in the United States and Canada: The Impact of a Reduction in Drug- and Alcohol-Related Deaths Using the Lives Saved Simulation Model | en_US |
| dc.type | Article | en_US |
| dc.identifier.doi | 10.1093/aje/kwz232 | |
