dc.contributor.author | Niarchou, Maria | |
dc.contributor.author | Byrne, Enda M. | |
dc.contributor.author | Trzaskowski, Maciej | |
dc.contributor.author | Sidorenko, Julia | |
dc.contributor.author | Kemper, Kathryn E. | |
dc.contributor.author | McGrath, John J. | |
dc.contributor.author | O' Donovan, Michael C. | |
dc.contributor.author | Owen, Michael J. | |
dc.contributor.author | Wray, Naomi R. | |
dc.date.accessioned | 2020-10-28T21:54:58Z | |
dc.date.available | 2020-10-28T21:54:58Z | |
dc.date.issued | 2020-02-03 | |
dc.identifier.citation | Niarchou, M., Byrne, E.M., Trzaskowski, M. et al. Genome-wide association study of dietary intake in the UK biobank study and its associations with schizophrenia and other traits. Transl Psychiatry 10, 51 (2020). https://doi.org/10.1038/s41398-020-0688-y | en_US |
dc.identifier.issn | 2158-3188 | |
dc.identifier.uri | http://hdl.handle.net/1803/16257 | |
dc.description.abstract | Motivated by observational studies that report associations between schizophrenia and traits, such as poor diet, increased body mass index and metabolic disease, we investigated the genetic contribution to dietary intake in a sample of 335,576 individuals from the UK Biobank study. A principal component analysis applied to diet question item responses generated two components: Diet Component 1 (DC1) represented a meat-related diet and Diet Component 2 (DC2) a fish and plant-related diet. Genome-wide association analysis identified 29 independent single-nucleotide polymorphisms (SNPs) associated with DC1 and 63 SNPs with DC2. Estimated from over 35,000 3rd-degree relative pairs that are unlikely to share close family environments, heritabilities for both DC1 and DC2 were 0.16 (standard error (s.e.) = 0.05). SNP-based heritability was 0.06 (s.e. = 0.003) for DC1 and 0.08 (s.e = 0.004) for DC2. We estimated significant genetic correlations between both DCs and schizophrenia, and several other traits. Mendelian randomisation analyses indicated a negative uni-directional relationship between liability to schizophrenia and tendency towards selecting a meat-based diet (which could be direct or via unidentified correlated variables), but a bi-directional relationship between liability to schizophrenia and tendency towards selecting a fish and plant-based diet consistent with genetic pleiotropy. | en_US |
dc.description.sponsorship | This research has been conducted using the UK Biobank Resource under Application Number 12505. This study was funded by the Wellcome Trust (110222/Z/15/Z)(MN). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Translational Psychiatry | en_US |
dc.rights | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | |
dc.source.uri | https://www.nature.com/articles/s41398-020-0688-y#rightslink | |
dc.title | Genome-wide association study of dietary intake in the UK biobank study and its associations with schizophrenia and other traits | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1038/s41398-020-0688-y | |