dc.contributor.author | Seidner, Douglas L. | |
dc.contributor.author | Gabe, Simon M. | |
dc.contributor.author | Lee, Hak-Myung | |
dc.contributor.author | Olivier, Clement | |
dc.contributor.author | Jeppesen, Palle Bekker | |
dc.date.accessioned | 2020-07-21T19:27:53Z | |
dc.date.available | 2020-07-21T19:27:53Z | |
dc.date.issued | 2020-05 | |
dc.identifier.issn | 0148-6071 | |
dc.identifier.uri | http://hdl.handle.net/1803/10223 | |
dc.description.abstract | Background Teduglutide response, in terms of parenteral support (PS) volume reduction, is associated with specific disease characteristics among adults with short bowel syndrome-associated intestinal failure (SBS-IF). Whether these associations apply to PS weaning with teduglutide is unknown.
Methods Adults with SBS-IF treated with teduglutide in the phase III STEPS study and open-label extensions STEPS-2 and STEPS-3 were included in the analysis. Patients required PS >= 3 times weekly for >= 12 months at enrollment. The study population was stratified 3 times to create 3 distinct analysis populations based on bowel anatomy, etiology, and baseline PS volume. Outcomes included characteristics of patients who achieved PS independence and total and percentage of patients who had >= 1, >= 2, and >= 3 d/wk off PS at the end of STEPS, STEPS-2, and STEPS-3.
Results Eight of 39 patients who received teduglutide in STEPS obtained PS independence during the STEPS study series. Patients required > 6 months of teduglutide treatment before enteral autonomy was achieved, regardless of underlying disease characteristics. Patients who attained PS independence and greater numbers of days per week off PS tended to have lower baseline PS volumes and noninflammatory bowel disease (non-IBD) etiology. Patients with >= 50% colon-in-continuity showed a trend for achieving greater numbers of days per week off PS.
Conclusion Although this analysis was limited by low patient numbers, results suggest that SBS-IF characteristics of lower baseline PS volume and non-IBD etiology were associated with PS reduction benefits with teduglutide in terms of days off per week and enteral autonomy. | en_US |
dc.description.sponsorship | This study was funded by Shire International GmbH, Zug, Switzerland, a member of the Takeda group of companies. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Journal of Parenteral and Enteral Nutrition | en_US |
dc.rights | © 2019 Takeda. Journal of Parenteral and Enteral Nutrition published by Wiley Periodicals, Inc. on behalf of American Society for Parenteral and Enteral Nutrition.
This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. | |
dc.source.uri | https://onlinelibrary.wiley.com/doi/full/10.1002/jpen.1687 | |
dc.subject | gastroenterology | en_US |
dc.subject | independence | en_US |
dc.subject | intestinal failure | en_US |
dc.subject | parenteral nutrition | en_US |
dc.subject | short bowel syndrome | en_US |
dc.subject | weaning | en_US |
dc.title | Enteral Autonomy and Days Off Parenteral Support With Teduglutide Treatment for Short Bowel Syndrome in the STEPS Trials | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1002/jpen.1687 | |