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The Children's Respiratory and Environmental Workgroup (CREW) birth cohort consortium: design, methods, and study population

dc.contributor.authorHartert, Tina
dc.identifier.citationGern, J. E., Jackson, D. J., Lemanske, R. F., Jr, Seroogy, C. M., Tachinardi, U., Craven, M., Hwang, S. Y., Hamilton, C. M., Huggins, W., O'Connor, G. T., Gold, D. R., Miller, R., Kattan, M., Johnson, C. C., Ownby, D., Zoratti, E. M., Wood, R. A., Visness, C. M., Martinez, F., Wright, A., … Bacharier, L. B. (2019). The Children's Respiratory and Environmental Workgroup (CREW) birth cohort consortium: design, methods, and study population. Respiratory research, 20(1), 115.
dc.description.abstractBackgroundSingle birth cohort studies have been the basis for many discoveries about early life risk factors for childhood asthma but are limited in scope by sample size and characteristics of the local environment and population. The Children's Respiratory and Environmental Workgroup (CREW) was established to integrate multiple established asthma birth cohorts and to investigate asthma phenotypes and associated causal pathways (endotypes), focusing on how they are influenced by interactions between genetics, lifestyle, and environmental exposures during the prenatal period and early childhood.Methods and resultsCREW is funded by the NIH Environmental influences on Child Health Outcomes (ECHO) program, and consists of 12 individual cohorts and three additional scientific centers. The CREW study population is diverse in terms of race, ethnicity, geographical distribution, and year of recruitment. We hypothesize that there are phenotypes in childhood asthma that differ based on clinical characteristics and underlying molecular mechanisms. Furthermore, we propose that asthma endotypes and their defining biomarkers can be identified based on personal and early life environmental risk factors. CREW has three phases: 1) to pool and harmonize existing data from each cohort, 2) to collect new data using standardized procedures, and 3) to enroll new families during the prenatal period to supplement and enrich extant data and enable unified systems approaches for identifying asthma phenotypes and endotypes.ConclusionsThe overall goal of CREW program is to develop a better understanding of how early life environmental exposures and host factors interact to promote the development of specific asthma endotypes.en_US
dc.description.sponsorshipCREW is funded by HHS/NIH grant 5UG3OD023282. Additional support was provided by individual cohorts' grants/contracts: Columbia University: P01ES09600, R01 ES008977, P30ES09089, R01 ES013163, R827027. Tucson Children's Respiratory Study (TCRS): NHLBI 132523. Infant Immune Study (IIS): HL-56177. Childhood Origins of Asthma Study (COAST): P01 HL070831, U10 HL064305, R01 HL061879. Urban Environment and Childhood Asthma Study (URECA): NO1-AI-25496, NO1-AI-25482, HHSN272200900052C, HHSN272201000052I, NCRR/NIH RR00052, M01RR00533, 1UL1RR025771, M01RR00071, 1UL1RR024156, UL1TR001079, 5UL1RR024992-02, NCATS/NIH UL1TR000040. Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS): R01 ES11170, R01 ES019890. The Epidemiology of Home Allergens and Asthma Study (EHAAS): R01 AI035786. Wayne County Health, Environment, Allergy and Asthma Longitudinal Study (WHEALS): R01 AI050681, R56 AI050681, R01 AI061774, R21 AI059415, K01 AI070606, R21 AI069271, R01 HL113010, R21 ES022321, P01 AI089473, R21 AI080066, R01 AI110450, R01 HD082147 and the Fund for Henry Ford Health System. Childhood Allergy Study (CAS): R01 AI024156, R03 HL067427, R01 AI051598, Blue Cross Foundation Johnson, and the Fund for Henry Ford Hospital. Microbes, Allergy, Asthma and Pets (MAAP): P01 AI089473 and Fund for Henry Ford Hospital. Infant Susceptibility to Pulmonary Infections and Asthma following RSV Exposure (INSPIRE): NIH/NIAID U19 AI 095227, NIH/NCATS UL1 TR 002243, NIH/NIAID K24 AI 077930, NIH/NHLBI R21 HD 087864, NIH/NHLBI X01 HL 134583. Wisconsin Infant Study Cohort (WISC): U19 AI104317, NCATS UL1TR000427, the charitable donors to the Marshfield Clinic Health System Foundation, and the Upper Midwest Agricultural Safety and Health Center (UMASH) U54 OH010170. RTI International, Research Triangle Park, North Carolina, USA: Funding from NIH for the Environmental influences of Child Health Outcomes (ECHO) Cohort Data Analysis Center (U24OD023382).en_US
dc.publisherRespiratory Reserarchen_US
dc.rightsOpen AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.
dc.subjectBirth cohorten_US
dc.subjectLongitudinal studyen_US
dc.titleThe Children's Respiratory and Environmental Workgroup (CREW) birth cohort consortium: design, methods, and study populationen_US

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