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Graphene-Based Nanomaterials: From Production to Integration With Modern Tools in Neuroscience

dc.contributor.authorKitko, Kristina E.
dc.contributor.authorZhang, Qi
dc.identifier.citationFrontiers in Systems Neuroscienceen_US
dc.identifier.othereISSN: 1662-5137
dc.description.abstractGraphene, a two-dimensional carbon crystal, has emerged as a promising material for sensing and modulating neuronal activity in vitro and in vivo. In this review, we provide a primer for how manufacturing processes to produce graphene and graphene oxide result in materials properties that may be tailored for a variety of applications. We further discuss how graphene may be composited with other bio-compatible materials of interest to make novel hybrid complexes with desired characteristics for bio-interfacing. We then highlight graphene's ever-widen utility and unique properties that may in the future be multiplexed for cross-modal modulation or interrogation of neuronal network. As the biological effects of graphene are still an area of active investigation, we discuss recent development, with special focus on how surface coatings and surface properties of graphene are relevant to its biological effects. We discuss studies conducted in both non-murine and murine systems, and emphasize the preclinical aspect of graphene's potential without undermining its tangible clinical implementation.en_US
dc.description.sponsorshipThis work is funded by National Institutes of Health, NIH; Grant No. OD00876101 and NS094738 to QZ.en_US
dc.rightsCopyright © 2019 Kitko and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.subjectgraphene oxideen_US
dc.subjectplasma membraneen_US
dc.titleGraphene-Based Nanomaterials: From Production to Integration With Modern Tools in Neuroscienceen_US

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