Browsing by Subject "cell signaling"

Now showing items 1-9 of 9

    • A Manganese-Handling Deficit in Huntington’s Disease Selectively Impairs ATM-p53 Signaling 
      Tidball, Andrew Martin (2014-09-29)
      Department: Neuroscience
      The essential micronutrient manganese is enriched in brain, especially the basal ganglia. We sought to identify neuronal signaling pathways responsive to neurologically relevant manganese levels, as previous data suggested ...
    • An Investigation of the GAPDH/Siah1 Pathway in Human Retinal Pericyte Apoptosis 
      Suarez, Sandra (2015-12-10)
      Department: Cell and Developmental Biology
      Diabetic Retinopathy (DR) is a leading cause of blindness worldwide, and its prevalence is growing. Current therapies for DR address only the later stages of the disease, are invasive and are of limited effectiveness. ...
    • ARRESTIN-MEDIATED EFFECTOR ACTIVATION 
      Perez, Ivette; 0000-0002-0482-8679 (2023-07-18)
      Department: Biochemistry
      Nonvisual arrestins (arrestin-2 and arrestin-3) regulate a wide range of signaling events, most notably when bound to active G protein-coupled receptors (GPCRs). Among the known effectors recruited by GPCR-bound arrestins ...
    • ARRESTIN-MEDIATED EFFECTOR ACTIVATION 
      Perez, Ivette; 0000-0002-0482-8679 (2023-07-18)
      Department: Biochemistry
      Nonvisual arrestins (arrestin-2 and arrestin-3) regulate a wide range of signaling events, most notably when bound to active G protein-coupled receptors (GPCRs). Among the known effectors recruited by GPCR-bound arrestins ...
    • Dissecting Pancreatic β-cell Stress Using Whole Transcriptome Sequencing 
      Stancill, Jennifer Susan (2017-03-29)
      Department: Cell and Developmental Biology
      Type 2 diabetes is characterized by failure of pancreatic β-cells to secrete adequate insulin to meet the needs of the body. This β-cell failure is thought to be caused by increased metabolic load due to mounting insulin ...
    • Insights into the Molecular Mechanisms of Phospholipase D-Mediated Cancer Cell Survival 
      Bruntz, Ronald Chase (2014-02-11)
      Department: Pharmacology
      The production of bioactive lipids by phospholipases has long been appreciated as an important mode of cellular communication. Phospholipase D (PLD) enzymes hydrolyze phosphatidylcholine to generate a choline headgroup and ...
    • Systems Biology of Mature Human B cells in Health and Illness 
      Wogsland, Cara Ellen (2017-06-19)
      Department: Microbiology and Immunology
      B cells play a crucial role in adaptive immunity. They perform a multitude of functions including antibody and cytokine production and antigen presentation. The human adaptive immune response would not function effectively ...
    • TGF-β reprograms metabolism and NKCC2 expression in renal tubule epithelial cells 
      Hunter, Kuniko; 0000-0002-2238-7950 (2023-02-16)
      Department: Biomedical Engineering
      Chronic kidney disease (CKD) is the ninth leading cause of death in the United States and affects 15% of the adult population globally. Renal transplantation, the best and most economical treatment, is severely limited by ...
    • The role of Nuclear Factor-kappa B (NF-kB) in the regulation of lung inflammation. 
      Everhart, Michael Brett (2004-12-01)
      Department: Cell and Developmental Biology
      The NF-kappaB pathway has been shown to play a critical role in both adaptive and innate immunity and has been implicated as a focal point for induction of lung inflammation by a variety of inflammatory stimuli; however, ...