Browsing by Subject "beta cell"
Now showing items 1-5 of 5
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(2017-03-29)Department: Cell and Developmental BiologyType 2 diabetes is characterized by failure of pancreatic β-cells to secrete adequate insulin to meet the needs of the body. This β-cell failure is thought to be caused by increased metabolic load due to mounting insulin ...
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(2021-08-16)Department: Chemical EngineeringBiochemical methods to quantify gene transcript, enzyme, and metabolite levels are widely used to assess metabolic pathway regulation. Though informative and even vital in some contexts, static measurements of biomolecule ...
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Ngn3-expressing progenitor heterogeneity drives endocrine lineage allocation in pancreas development (2015-11-17)Department: Cell and Developmental BiologyDiabetes is a worldwide health issue. In both type I and late stage type II diabetes, significant beta-cell loss causes insulin deficiency and hyperglycemia. Replenishing beta cells is a promising therapy and it requires ...
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(2017-04-07)Department: Molecular Physiology and BiophysicsMisregulated hormone secretion from the islets of Langerhans is central to the pathophysiology of Diabetes. While insulin plays a key role in glucose regulation and the modulation of secretion has immediate clinical ...
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(2008-09-29)Department: Molecular Physiology and BiophysicsMOLECULAR PHYSIOLOGY AND BIOPHYSICS THE ROLE OF FOXM1 IN PANCREATIC BETA CELL MASS REGENERATION AND EXPANSION AMANDA ACKERMANN MISFELDT Dissertation under the direction of Maureen Gannon, Ph.D. The size of an organism’s ...