Browsing by Subject "H3"
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Total Synthesis and Biological Evaluation of Alkaloid Natural Products (+)-7-Bromotrypargine and Phidianidines A & B and the Development of a Novel Class of Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 1 (2013-07-29)Department: Chemical and Physical BiologyThe first total synthesis of (+)-7-bromotrypargine, a β-carboline alkaloid from Ancornia sp. was completed in 9 steps, 8 steps longest linear sequence, and 40% overall yield. Biological characterization found that ...