Browsing by Subject "DNA glycosylase"
Now showing items 1-6 of 6
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(2014-06-25)Department: Chemical and Physical BiologyThe methylation state of DNA is important for gene expression, gene imprinting, X-chromosome inactivation, and transposon silencing in mammals and plants. DNA methylation is established by methyltransferases to mark a ...
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(2022-03-21)Department: Biological SciencesDNA is a fundamental biomolecule of life which stores the genetic information of organisms and drives many of the evolutionary processes in nature. Despite this, DNA is subject to physical and chemical damage from environmental ...
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(2022-03-21)Department: Biological SciencesDNA is a fundamental biomolecule of life which stores the genetic information of organisms and drives many of the evolutionary processes in nature. Despite this, DNA is subject to physical and chemical damage from environmental ...
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(2018-06-11)Department: Biological SciencesDNA glycosylases preserve genome integrity and define the specificity of the base excision repair pathway for discreet, detrimental modifications. Bacterial HEAT-like repeat glycosylases AlkC and AlkD are specific for ...
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(2013-03-04)Department: Biological SciencesWork presented in this dissertation details structural and biochemical characterization of three yeast alkylpurine DNA glycosylases – Mag1 and Mag2 from S. pombe and Mag from S. cerevisiae. I determined high resolution ...
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(2011-02-17)Department: Chemical and Physical BiologyAlkylating agents covalently modify DNA bases to generate a chemically diverse set of lesions including cytotoxic N3-methyladenine (3mA) bases and mutagenic 1,N6-ethenoadenine (εA) and N7-methylguanine (7mG). To maintain ...