Browsing by Subject "DNA adducts"
Now showing items 1-7 of 7
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(2017-12-06)Department: ChemistryPart A: Cyclooxygenase-2 (COX-2) oxygenates arachidonic acid (AA) and its ester analog, 2-arachidonoylglycerol (2-AG), to prostaglandins (PGs) and prostaglandin glyceryl esters (PG-Gs), respectively. Although the efficiency ...
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(2013-04-16)Department: ChemistryAflatoxin B1 (AFB1), a carcinogenic mycotoxin produced by the common agricultural contaminant A. flavus, has been implicated in the high rates of hepatocellular carcinoma observed in some developing countries. Upon ...
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(2015-02-26)Department: Chemical and Physical Biology2-Amino-3-methylimidazo-[4,5-f]quinoline, IQ, has been identified as one of the most genotoxic materials according to Ames assays and animal studies. IQ is during high temperature cooking of meats and is classified as ...
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(2005-11-02)Department: BiochemistryTopoisomerase II is an essential enzyme that controls DNA topology. This enzyme generates a protein-linked DNA break as a catalytic intermediate. This intermediate, known as the cleavage complex, is present in very low ...
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(2008-03-13)Department: BiochemistryMultiple exocyclic DNA adducts arise from reactions of lipid and DNA peroxidation products with DNA bases. These endogenous lesions are mutagenic; therefore, monitoring adduct levels may provide a means of assessing genomic ...
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(2009-07-25)Department: ChemistryButadiene monoepoxide (BDO) is the major metabolite of butadiene (BD), a widely used petrochemical and known human and animal carcinogen. BD metabolites may be involved in BD-induced carcinogenicity primarily through the ...
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(2007-10-08)Department: ChemistryMethylating agents react with DNA to give the cationic N7-methyl deoxyguanosine adduct, which can undergo hydrolytic opening of the imidazole ring to form 2,6-diamino-4-hydroxy-N5-(methyl)-formamido-pyrimidine (MeFAPy-dGuo) ...