Browsing by Subject "DNA Adducts"
Now showing items 1-2 of 2
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(2008-12-15)Department: ChemistryExposure to endogenous and exogenous chemicals can lead to modification of DNA and potentially lead to cancer. Frameshift mutations may be a consequence of these modifications to DNA. Oligonucleotides were synthesized ...
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(2015-11-30)Department: Chemistry2-Amino-3-methylimidizo-[4,5-ʄ]-quinoline (IQ), a potent dietary mutagen, forms DNA adducts at the N² and C8-positions of 2ʹ-deoxyguanosine. IQ induces G to A transitions and G to T transversions in eukaryotic cells. The ...