Browsing by Department "Cell & Developmental Biology"
Now showing items 1-13 of 13
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(2020-01-17)Department: Cell & Developmental BiologyBasement membranes are sheet-like extracellular matrixes that can be found on the basal surface of epithelial and endothelial cells, surrounding muscles and other organs, and in association with neurons. In addition to ...
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(2020-07-22)Department: Cell & Developmental BiologyHere, we characterize spatial distribution of the Golgi complex in human cells. In contrast to the prevailing view that the Golgi compactly surrounds the centrosome throughout interphase, we observe characteristic differences ...
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(2021-01-06)Department: Cell & Developmental BiologyEpithelial cells possess intrinsic mechanisms to maintain an appropriate cell density for normal tissue morphogenesis and homeostasis. Defects in such mechanisms likely contribute to hyperplasia and cancer initiation. To ...
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(2020-06-16)Department: Cell & Developmental BiologyHuman casein kinase 1 delta (CK1δ) and epsilon (CK1ε) are members of a conserved family of ubiquitously expressed serine/threonine kinases that regulate multiple cellular processes including endocytosis, circadian rhythm, ...
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(2021-02-04)Department: Cell & Developmental BiologyCytokinesis is the final step in cell division in which two daughter cells physically separate. In order to complete this process, many eukaryotes, including Schizosaccharomyces pombe, assemble an actin- and myosin-based ...
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(2020-05-14)Department: Cell & Developmental BiologyAlternating hemiplegia of childhood (AHC) is a rare and devastating neurodevelopmental disorder caused by de novo heterozygous missense mutations in ATP1A3, a crucial gene encoding the 3 subunit of the Na,K-ATPase (NKA) ...
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(2020-08-31)Department: Cell & Developmental BiologyThe response to injury in the stomach is a balancing act between repair mechanisms and the processes that drive carcinogenesis. While the recruitment of reparative lineages is integral to the protection and restoration of ...
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Revealing MCL-1 Regulation of Mitochondrial Dynamics in Human Pluripotent Stem Cell-Derived Systems (2021-02-03)Department: Cell & Developmental BiologyThe B cell CLL/lymphoma-2 (BCL-2) family of proteins control the mitochondrial pathway of cell death, also known as intrinsic apoptosis. The ability of the cell to sense stress and translate it into a death signal has been ...
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(2020-12-06)Department: Cell & Developmental BiologyThe oncoprotein transcription factor MYC is a major driver of malignancy and a highly-validated target for development of anti-cancer therapies. It has, however, proven challenging to inhibit MYC directly. Novel strategies ...
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(2020-09-23)Department: Cell & Developmental BiologyThe molecular motor myosin-II (MII) generates mechanical tension on the actin cytoskeleton to drive cell shape changes during cell division, cell migration and tissue morphogenesis. How these actomyosin networks generate ...
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(2020-07-19)Department: Cell & Developmental BiologySin3a and Sin3b are paralogous transcriptional coregulators that direct cellular differentiation, survival, and function. Mouse Sin3a and Sin3b are co-produced in most pancreatic cells during embryogenesis but become much ...
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(2021-02-10)Department: Cell & Developmental BiologyWDR5 is a conserved WD40-repeat protein that rose to prominence through its role in epigenetic complexes, including the KMT2 (MLL/SET) enzymes that deposit histone H3 lysine 4 methylation and the non-specific lethal complex ...
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(2020-01-16)Department: Cell & Developmental BiologyWDR5 is a highly-conserved nuclear protein that performs multiple scaffolding functions in the context of chromatin. Efforts to better understand WDR5 have been complicated by its many functions in the nucleus, and thwarted ...