Now showing items 1-20 of 27

    • O'Connor, James Thomas; 0000-0003-2642-1594 (2022-02-16)
      Department: Cell & Developmental Biology
      When an organism is injured, the damaged tissue recognizes the presence and severity of the wound and rapidly responds to repair the injury and restore proper tissue functionality. But how do cells first detect the presence ...
    • Ramos-Lewis, William David; 0000-0002-4627-4571 (2020-01-17)
      Department: Cell & Developmental Biology
      Basement membranes are sheet-like extracellular matrixes that can be found on the basal surface of epithelial and endothelial cells, surrounding muscles and other organs, and in association with neurons. In addition to ...
    • Narasimhan, Shwetha; 0000-0002-8027-7880 (2022-05-16)
      Department: Cell & Developmental Biology
      The ventral actin cytoskeleton is a dynamic network of actin stress fibers (VSFs) and focal adhesions that produces contractile forces integral in cell polarization, migration and extracellular matrix remodeling. My research ...
    • Frye, Keyada Briana; 0000-0001-8321-1863 (2020-07-22)
      Department: Cell & Developmental Biology
      Here, we characterize spatial distribution of the Golgi complex in human cells. In contrast to the prevailing view that the Golgi compactly surrounds the centrosome throughout interphase, we observe characteristic differences ...
    • Cuentas Condori, Andrea Aurora; 0000-0002-4847-0031 (2021-06-15)
      Department: Cell & Developmental Biology
      Multicellular organisms adapt to the environment by sensing it and reacting to it through neuronal networks that are in place to transform a stimulus into a behavioral effect. A functional nervous system requires pruning ...
    • Scurrah, Cherie Rose; 0000-0002-8003-9022 (2021-04-02)
      Department: Cell & Developmental Biology
      Cancer is a heterogeneous disease displaying a variety of cell populations inter- and intra-tumorally. This heterogeneity poses a challenge to cancer treatment, as more heterogeneous cellular populations are more prone to ...
    • Giblin, Meredith J; 0000-0002-1135-6729 (2021-11-19)
      Department: Cell & Developmental Biology
      Diabetic retinopathy (DR) is the leading cause of blindness in working age Americans. Chronic low-grade retinal inflammation is an essential contributor to the pathogenesis of DR, as it is known to drive many of the ...
    • Strothman, Claire E; 0000-0001-7849-0626 (2021-06-08)
      Department: Cell & Developmental Biology
      Dynamics and Regulation of Microtubule Minus Ends Microtubules are an integral part of the cytoskeletal system in cells and serve essential roles in cell division, intracellular transport, and morphogenesis. Microtubules ...
    • Romero Morales, Alejandra Ines; 0000-0001-9087-1907 (2022-02-16)
      Department: Cell & Developmental Biology
      The brain is one of the most complex and mysterious organs in the human body. Centuries of research have shown that it is generated by a finely orchestrated series of events that take place in the first weeks of life up ...
    • Florian, Andrea C.; 0000-0003-2809-4662 (2022-03-17)
      Department: Cell & Developmental Biology
      Rhabdoid tumors (RT) are rare and deadly pediatric cancers driven by loss of SMARCB1, which encodes the SNF5 component of the SWI/SNF chromatin remodeler. Loss of SMARCB1 is associated with a complex set of phenotypic ...
    • Fomicheva, Maria; 0000-0002-0281-0467 (2021-01-06)
      Department: Cell & Developmental Biology
      Epithelial cells possess intrinsic mechanisms to maintain an appropriate cell density for normal tissue morphogenesis and homeostasis. Defects in such mechanisms likely contribute to hyperplasia and cancer initiation. To ...
    • Ortolano, Natalya Anne; 0000-0002-6355-7362 (2021-05-13)
      Department: Cell & Developmental Biology
      The body of work presented in this dissertation details the characterization of a novel human-cell derived model of the understudied, non-canonical cullin scaffold CUL9. Unlike other cullins, previous efforts to characterize ...
    • Guillen, Rodrigo; 0000-0002-9807-6155 (2020-06-16)
      Department: Cell & Developmental Biology
      Human casein kinase 1 delta (CK1δ) and epsilon (CK1ε) are members of a conserved family of ubiquitously expressed serine/threonine kinases that regulate multiple cellular processes including endocytosis, circadian rhythm, ...
    • Farmer, Veronica Jeanna; 0000-0003-3857-5793 (2022-03-29)
      Department: Cell & Developmental Biology
      The microtubule network in cells continuously remodels to facilitate its vital functions in cell division, cell motility and intracellular transport. Organization of the microtubule network is enabled by regulation of the ...
    • Snider, Chloe Elizabeth; 0000-0002-7206-675X (2021-02-04)
      Department: Cell & Developmental Biology
      Cytokinesis is the final step in cell division in which two daughter cells physically separate. In order to complete this process, many eukaryotes, including Schizosaccharomyces pombe, assemble an actin- and myosin-based ...
    • Snow, John Patrick; 0000-0002-8569-1431 (2020-05-14)
      Department: Cell & Developmental Biology
      Alternating hemiplegia of childhood (AHC) is a rare and devastating neurodevelopmental disorder caused by de novo heterozygous missense mutations in ATP1A3, a crucial gene encoding the 3 subunit of the Na,K-ATPase (NKA) ...
    • Neininger, Abigail Carson; 0000-0001-5104-4407 (2021-09-20)
      Department: Cell & Developmental Biology
      The heart is an essential organ that facilitates blood flow throughout the body, transporting oxygenated blood from the lungs to the body and in transporting deoxygenated blood from the body to the lungs. Behind each beat ...
    • Dudek, Karrie; 0000-0003-1676-9327 (2021-06-24)
      Department: Cell & Developmental Biology
      To better understand how Insm1, Neurod1 and Pax6 contribute to the formation and function of pancreatic endocrine cells I performed comparative immunohistochemical, transcriptomic, functional enrichment, and RNA splicing ...
    • Meyer, Anne R.; 0000-0002-5668-6756 (2020-08-31)
      Department: Cell & Developmental Biology
      The response to injury in the stomach is a balancing act between repair mechanisms and the processes that drive carcinogenesis. While the recruitment of reparative lineages is integral to the protection and restoration of ...
    • Rasmussen, Megan Loraine; 0000-0002-8056-6092 (2021-02-03)
      Department: Cell & Developmental Biology
      The B cell CLL/lymphoma-2 (BCL-2) family of proteins control the mitochondrial pathway of cell death, also known as intrinsic apoptosis. The ability of the cell to sense stress and translate it into a death signal has been ...