Browsing by Department "Biomedical Sciences"

Now showing items 1-5 of 5

    • Disentangling Sources of Phenotypic Variability in Oncogene-addicted Cancers 
      Hayford, Corey Eduardo; 0000-0002-3006-4852 (2021-03-08)
      Department: Biomedical Sciences
      Tumor heterogeneity and plasticity are key contributors to treatment insensitivity and eventual recurrence in oncogene-addicted cancers. Sources of this variability have been ascribed to genetic, epigenetic, stochastic, ...
    • Flexibility and distributive synthesis regulate RNA priming and handoff in human DNA polymerase α-primase 
      Cordoba, John James; 0000-0001-5400-163X (2023-10-27)
      Department: Biomedical Sciences
      DNA replication in eukaryotes relies on the synthesis of a ~30-nucleotide chimeric RNA/DNA primer strand through the dual action of the heterotetrameric polymerase α-primase (pol-prim) enzyme. Synthesis of an initial ...
    • New Insights into the Regulation of the Innate Immune Response During Gastrointestinal Infection and Inflammation 
      Latour, Yvonne; 0000-0002-9319-8268 (2022-10-31)
      Department: Biomedical Sciences
      The root of many gastrointestinal diseases is a dysregulated immune response. Within the gut, the immune system is constantly active and crucial to maintaining homeostasis and intercepting potential pathogens. In this ...
    • Systematic analysis of B-cell repertoires 
      Chen, Elaine Chang; 0000-0001-7883-8039 (2022-03-21)
      Department: Biomedical Sciences
      The B-cell repertoire within an individual is a library of antibodies to all the pathogens an individual had been exposed to in the past. Many methods have been implemented to dig into this rich source of antibodies to ...
    • Systematic analysis of B-cell repertoires 
      Chen, Elaine Chang; 0000-0001-7883-8039 (2022-03-21)
      Department: Biomedical Sciences
      The B-cell repertoire within an individual is a library of antibodies to all the pathogens an individual had been exposed to in the past. Many methods have been implemented to dig into this rich source of antibodies to ...