Browsing by Author "O'Brien, Richard"
Now showing items 1-4 of 4
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Townsend, Shannon; 0000-0001-9171-8031 (2023-08-15)Department: Molecular Physiology & BiophysicsCCN2 is a matricellular protein that stimulates beta-cell mass expansion during situations of sub-optimal beta-cell mass such as during embryogenesis, after beta-cell ablation, and during pregnancy. It was hypothesized ...
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Graff, Sarah M; 0000-0003-0419-4706 (2021-06-14)Department: Molecular Physiology & BiophysicsThe two-pore domain K+ channel, TALK-1 modulates pancreatic β- and δ-cell Ca2+ ([Ca2+]c) entry and endoplasmic reticulum (ER) Ca2+ ([Ca2+]ER) handling thereby impacting hormone secretion and glucose tolerance. To investigate ...
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Walker, John T.; 0000-0002-6552-5401 (2021-06-03)Department: Molecular Physiology & BiophysicsPancreatic islets are central in the control of blood glucose and their dysfunction is a hallmark of diabetes. Incomplete knowledge of islet biology currently prevents diagnostic and therapeutic approaches based on molecular ...
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Elsakr, Joseph; 0000-0002-2047-0339 (2020-03-13)Department: OtherThe Developmental Origins of Health and Disease (DOHaD) Hypothesis postulates that the in utero environment influences postnatal health and plays a role in disease etiology. Studies in humans and animal models have ...