Browsing by Author "Hak-Joon Sung"
Now showing items 1-20 of 22
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Weis, Jared Anthony (2011-08-23)Department: Biomedical EngineeringAssessment of the restoration of load-bearing function is the central goal in the study of bone fracture healing. However, bone fracture calluses are inhomogeneous and irregular materials and this complexity has led to ...
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Yu, Shann Claybourne Say (2012-12-03)Department: Biomedical EngineeringMacrophages have been proposed as a potential therapeutic target because of their central role in the progression of a number of debilitating diseases, such as cancer and cardiovascular diseases. However, macrophages are ...
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Sarett, Samantha Mara (2014-11-25)Department: Biomedical EngineeringClinical translation of siRNA therapeutics has been limited by the inability to effectively overcome the rigorous delivery barriers associated with intracellular-acting biologics. Here, in order to address both potency and ...
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Development of hemodynamic targeted theranostic nanoparticles for the prevention of atherosclerosis Hofmeister, Lucas Hudson (2015-03-20)Department: Biomedical EngineeringIn regions of the circulation where vessels are straight and unbranched, blood flow is laminar and unidirectional. In contrast, at sites of curvature, branch points and regions distal to stenoses blood flow becomes disturbed. ...
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Evans, Brian Connor (2015-04-05)Department: Biomedical EngineeringPeptide-based therapeutics hold significant therapeutic potential for use in a variety of clinical applications ranging from cancer to cardiovascular disease. However, the potential of peptide-based therapeutics is limited ...
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Boire, Timothy Charles (2013-12-12)Department: Biomedical EngineeringA series of novel, physiologically-responsive poly(ε-caprolactone)-co-(α-allyl carboxylate-ε-caprolactone) [x%PCL-y%ACPCL (x and y: molar ratio)] shape memory polymers (SMPs) were synthesized with excellent shape memory ...
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Prieto-Ballengee, Edna Margarita (2013-12-04)Department: Chemical EngineeringThere is a compelling clinical need for grafts with initial bone-like mechanical properties that remodel and promote healing of bone defects. This dissertation describes the development and characterization of biodegradable ...
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Lee, Sue Hyun (2013-12-12)Department: Biomedical EngineeringGelatin is a hydrolyzed and denatured form of collagen, which comprises the majority of extracellular matrix. Despite its numerous advantages for tissue engineering, its use as a thermostable hydrogel has been achieved ...
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Harmata, Andrew James (2015-04-02)Department: Chemical EngineeringOf the nearly 1.6 million bone graft procedures conducted annually to treat bone fractures in the U.S., ~25% of these fracture patients require rehospitalization due to graft failure. Injectable and settable synthetic bone ...
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Yu, Shann Claybourne Say (2009-12-21)Department: Biomedical EngineeringWe demonstrate a flexible, tunable scheme for synthesizing multifunctional, ultrasmall superparamagnetic iron oxide nanoparticles (USPIOs) and its application to the area of magnetic relaxation switches. USPIO cores (10nm) ...
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Kilchrist, Kameron V. (2016-04-11)Department: Biomedical EngineeringElectrostatic complexation of a cationic MAPKAP kinase 2 inhibitory (MK2i) peptide with the anionic, pH-responsive polymer poly(propylacrylic acid) (PPAA) yields MK2i nano-polyplexes (MK2i-NPs) that significantly increase ...
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Sewell-Loftin, Mary Kathryn (2014-04-01)Department: Biomedical EngineeringNearly 300,000 heart valve (HV) replacement surgeries are performed annually, including both pediatric patients with valvular defects and elderly patients suffering from degenerative or calcific valve diseases. Worldwide, ...
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Crowder, Spencer William (2011-04-15)Department: Biomedical EngineeringPolymer properties can be altered by copolymerizing subunits with specific physicochemical characteristics. Vascular stent materials require biocompatibility, mechanical strength, and prevention of restenosis. Here we ...
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Multiplex biomaterial matrix cues regulate redox status and stemness in human mesenchymal stem cells Crowder, Spencer William (2014-04-26)Department: Biomedical EngineeringHuman mesenchymal stem cells (hMSCs) offer therapeutic potential for clinical applications but exhibit a decline in overall health when isolated from aging patients or serially expanded in vitro. hMSCs have been shown to ...
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Lubbers, Brad Ryan (2015-03-24)Department: Biomedical EngineeringCalorimetry has many applications in the physical and life sciences including measuring phase changes, determining reaction equilibria, detecting protein binding events, and quantifying enzyme kinetics. Towards the goal ...
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Zachman, Angela Laurie (2011-04-15)Department: Biomedical EngineeringBoth angiogenesis and inflammation are inescapable in vivo responses to any type of biomaterials implanted for regeneration. Continuous progress has been made in biomaterial design to facilitate tissue interactions with ...
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Balikov, Daniel Adam (2017-02-08)Department: Biomedical EngineeringRegenerative medicine has the potential to revolutionize how medical professionals approach combating and treating disease. Over the past several decades, human mesenchymal stem cells (hMSCs) have become one of the most ...
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Martin, John Robert (2016-12-12)Department: Biomedical EngineeringThe fields of regenerative medicine and tissue engineering are founded on the usage of bulk-scale, biodegradable material implants that help direct the repair of damaged or non-functioning tissues or organs. Biodegradable ...
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Marasco, Christina C (2012-07-30)Department: Biomedical EngineeringThe progression of science and medicine is often predicated by advancements in technology. Particularly, automation has played a large role in many of these technological advancements, allowing for progress to occur at a ...
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Chen, Joseph (2015-03-26)Department: Biomedical EngineeringCalcific aortic valve disease (CAVD) is the predominant valvular disease in the developed world, affecting over five million individuals in the United States alone and manifests itself as a progressive disease resulting ...