Browsing by Author "Earl Ruley"
Now showing items 1-18 of 18
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Greenplate, Allison Rae (2018-03-29)Department: Microbiology and ImmunologyThe immune system is a complex network of cells spread throughout the body, spanning dozens of tissue types and locations. A complete understanding of a systemic immune response, like those required for the regression of ...
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Beachboard, Dia Chenelle (2015-02-11)Department: Microbiology and ImmunologyCoronaviruses are positive-sense RNA viruses that cause significant diseases in humans. Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) caused a pandemic in 2002-2003, and Middle East Respiratory Syndrome coronavirus ...
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Cox, Reagan Josephine Greene (2012-12-07)Department: Microbiology and ImmunologyThis project is concerned with how the recently discovered paramyxovirus, human metapneumovirus (HMPV), interacts with host cells to initiate entry. In this dissertation I explore whether the HMPV fusion protein interacts ...
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Freeman, Megan Culler (2014-08-04)Department: Microbiology and ImmunologyCoronaviruses (CoVs) are positive-strand RNA viruses that induce modifications to host-cell cytoplasmic membranes during formation of replication complexes. While important for viral replication, the dynamics of this process ...
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Craven, Ryan Eric (2016-03-04)Department: Microbiology and ImmunologyClostridium sordellii infections cause gangrene and edema in humans and gastrointestinal infections in livestock. The two principle virulence factors, TcsH and TcsL, are highly homologous to C. difficile TcdA and TcdB, ...
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Zamora Vargas, Paula Francisca (2018-07-10)Department: Microbiology and ImmunologyViral nonstructural proteins, which are not packaged into virions, are essential for the replication of most viruses. Reovirus, a nonenveloped, double-stranded RNA (dsRNA) virus, encodes three nonstructural proteins that ...
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Sutherland, Danica Marie (2018-08-22)Department: Microbiology and ImmunologyViral encephalitis is a serious and life-threatening inflammation of the central nervous system (CNS). However, mechanisms of viral neuroinvasion and disease pathogenesis in the CNS are often poorly understood. Mammalian ...
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Burse, Mallori Jacole (2017-12-05)Department: Microbiology and ImmunologyThe host protein cyclophilin A (CypA) can both stimulate and inhibit HIV-1 infection through its interaction with the viral capsid (CA). CypA enhances the early stages of HIV-1 infection in part by promoting nuclear import ...
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Williams, Christopher Lawrence (2013-07-29)Department: Microbiology and ImmunologyCD4+ T cells developing toward a Th2 fate express IL-4, IL-5, and IL-13 while inhibiting production of cytokines associated with other Th types, such as the Th1 cytokine IFN-γ. IL-4–producing Th2 effector cells give rise ...
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Antar, Annukka Aida Rose (2008-12-30)Department: Microbiology and ImmunologyDiverse families of viruses bind immunoglobulin superfamily (IgSF) proteins located in tight junctions and adherens junctions of epithelium and endothelium. However, little is known about the roles of these receptors in ...
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Cao, Shang (2005-12-13)Department: Microbiology and ImmunologyNON-REDUNDANT FUNCTIONS OF THE MOUSE SSRP1 AND PFDN1 GENES REVEALED BY GENE TARGETING AND GENE ENTRAPMENT SHANG CAO Dissertation under the direction of Professor Henry Earl Ruley In the post-genome era, gene targeting ...
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Doyle, Joshua David (2012-12-12)Department: Microbiology and ImmunologyA common feature of nonenveloped virus replication is the requirement for structural capsid rearrangements to facilitate productive cell entry. Using mammalian orthoreovirus as a model, my work has focused on defining ...
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Germane, Katherine Lynn (2011-08-24)Department: Microbiology and ImmunologyVirulence effectors are a diverse group of proteins secreted by pathogenic bacteria to enable infection by concertedly acting to obstruct host defenses. A major step during invasion and spread for intracellular pathogens ...
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Benefield, Desirée Allyn (2014-07-03)Department: Microbiology and ImmunologyMy project has focused on understanding the structural organization of the clostridial neurotoxins, botulinum and tetanus, that are the causative agents of the neuroparalytic diseases botulism and tetanus. Once the toxins ...
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Campbell, Jacquelyn Andrea (2005-12-05)Department: Microbiology and ImmunologyMammalian reoviruses are nonenveloped, double-stranded RNA viruses that serve as important models for studies of viral neuropathogenesis. Reovirus disease is initiated by binding of the virus to receptors on the surface ...
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Yufenyuy, Ernest Limnyuy (2013-04-23)Department: Microbiology and ImmunologyThis dissertation discusses the role of intersubunit interfaces in HIV-1 capsid assembly and stability. In this study I showed the presence of both the NTD-CTD and CTD-CTD trimer interfaces in mature HIV-1 virions using ...
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Burnett, Atuhani Seth (2008-02-11)Department: Microbiology and ImmunologyAPOBEC3G is a cytidine deaminase that inhibits HIV replication at a post-entry step in replication. APOBEC3G must be incorporated into the virus particle during assembly in order to inhibit HIV during the next round of ...
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Bokiej, Magdalena (2012-08-21)Department: Microbiology and ImmunologyThis dissertation research was focused on elucidating mechanisms at the reovirus-host interface that allow successful completion of the initial replicative steps and lead to viral protein synthesis. During the course of ...