Browsing by Author "David Piston"
Now showing items 1-10 of 10
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Plank, Jennifer Lynn (2011-12-10)Department: Cell and Developmental BiologyDiabetes mellitus affects approximately 150 million people worldwide. This disease is characterized by hyperglycemia resulting from dysfunctional pancreatic beta cells. Current treatments for diabetics are inadequate because ...
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Design and Characterization of a Microfluidic System for Scanning Transmission Electron Microscopy Ring, Elisabeth Ariel (2010-06-29)Department: Chemical and Physical BiologyFor years it has been a goal to image biological specimens in liquid in the electron microscope, avoiding possible artifacts introduced by sample preparation procedures. Here, I present a microfluidic system that allows ...
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Caldwell, Brittany Catherine (2016-04-04)Department: Biomedical EngineeringInsulin resistance together with insufficient insulin secretion leads to the development of type II diabetes mellitus. Glucose-stimulation of insulin secretion has been extensively studied, but other pathways that regulate ...
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Electron Beams from Needle Photocathodes and a New Theory of the Smith-Purcell Free-Electron Laser Boulware, III, Charles H. (2007-02-15)Department: PhysicsA promising source of radiation in the important terahertz (THz) region of the spectrum is the Smith-Purcell free-electron laser (SPFEL). This dissertation presents a new theory of the SPFEL, taking into account dispersion ...
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Keigher, Laura Elizabeth (2012-12-03)Department: Chemical and Physical BiologyiASPP (inhibitory member of the apoptosis stimulating protein of p53 family) is known to inhibit the important tumor suppressors p53 and p73. Indeed, iASPP is over-expressed in several cancer types and is associated with ...
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Ngn3-expressing progenitor heterogeneity drives endocrine lineage allocation in pancreas development Liu, Jing (2015-11-17)Department: Cell and Developmental BiologyDiabetes is a worldwide health issue. In both type I and late stage type II diabetes, significant beta-cell loss causes insulin deficiency and hyperglycemia. Replenishing beta cells is a promising therapy and it requires ...
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Elliott, Amicia Devin (2014-06-18)Department: Molecular Physiology and BiophysicsDiabetes mellitus has been a disease of increasing prevalence for nearly a century and is attributed to a dysregulation of hormones secreted from the pancreatic Islets of Langerhans; insulin from β-cells and glucagon from ...
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Frick, Peter Lee (2014-11-24)Department: Chemical and Physical BiologyIntratumor heterogeneity underlies the failure of targeted cancer therapy. The origins of this phenotypic variability derive from the coincident contributions of genetic, non-genetic, and stochastic factors. However, few ...
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Reissaus, Christopher Alan (2017-04-07)Department: Molecular Physiology and BiophysicsMisregulated hormone secretion from the islets of Langerhans is central to the pathophysiology of Diabetes. While insulin plays a key role in glucose regulation and the modulation of secretion has immediate clinical ...
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Potter, Leah Ashley (2011-12-04)Department: Molecular Physiology and BiophysicsPluripotent stem cells, because of their ability to differentiate into any cell type, have been widely advocated as a means of producing a nearly unlimited source of new insulin-producing β cells for the treatment of ...