Browsing by Author "David Jacobson"

Now showing items 1-7 of 7

    • Dissecting Pancreatic β-cell Stress Using Whole Transcriptome Sequencing 
      Stancill, Jennifer Susan (2017-03-29)
      Department: Cell and Developmental Biology
      Type 2 diabetes is characterized by failure of pancreatic β-cells to secrete adequate insulin to meet the needs of the body. This β-cell failure is thought to be caused by increased metabolic load due to mounting insulin ...
    • Exploring the Function of G6PC2 in Pancreatic Islet Beta Cells 
      Boortz, Kayla Ann (2016-10-03)
      Department: Molecular Physiology and Biophysics
      MOLECULAR PHYSIOLOGY & BIOPHYSICS Exploring the Function of G6PC2 in Pancreatic Islet Beta Cells Kayla Boortz Dissertation under the direction of Professor Richard O’Brien, Ph.D. G6PC2 encodes an islet-specific ...
    • Exploring the Role of ZnT8 in Islet Beta Cell Function and Type 2 Diabetes 
      Syring, Kristen Elizabeth (2017-08-02)
      Department: Molecular Physiology and Biophysics
      Type 2 diabetes (T2D) is characterized by hyperglycemia, which arises due to insulin resistance and beta cell failure and/or decreased beta cell mass. Genome-wide association studies have shown that single nucleotide ...
    • Paracrine regulation of glucagon secretion from pancreatic islets 
      Elliott, Amicia Devin (2014-06-18)
      Department: Molecular Physiology and Biophysics
      Diabetes mellitus has been a disease of increasing prevalence for nearly a century and is attributed to a dysregulation of hormones secreted from the pancreatic Islets of Langerhans; insulin from β-cells and glucagon from ...
    • Regulated Glucagon Secretion from Islet and Pseudo-Islet Alpha Cells 
      Reissaus, Christopher Alan (2017-04-07)
      Department: Molecular Physiology and Biophysics
      Misregulated hormone secretion from the islets of Langerhans is central to the pathophysiology of Diabetes. While insulin plays a key role in glucose regulation and the modulation of secretion has immediate clinical ...
    • Role of KCC3 in the Hereditary Sensory Motor Neuropathy: HMSN/ACC 
      Ding, Jinlong (2014-12-01)
      Department: Molecular Physiology and Biophysics
      Hereditary motor and sensory neuropathy associated with agenesis of the corpus callosum (HMSN/ACC or ACCPN) is an autosomal recessive disease caused by the disruption of the SLC12A6 gene, which encodes the K–Cl cotransporter-3 ...
    • The reversal of dopamine transporter function is governed by plasma membrane interactions and disrupted by genetic variations 
      Hamilton, Peter James (2014-12-08)
      Department: Neuroscience
      Dopaminergic neurotransmission plays an important role in the regulation of cognitive, behavioral, and motor functions. Abnormalities in the dopamine (DA) system have been implicated in neuropsychiatric disorders including ...