Browsing by Author "Christine M. Eischen"

Now showing items 1-3 of 3

    • Regulation of Stalled Replication Forks by ATR 
      Couch, Frank Benjamin IV (2014-04-17)
      Department: Biochemistry
      Errors during DNA replication lead to mutations which contribute to cancer development. To deal with these challenges, cells contain an innate machinery known as the replication stress response. ATR is the master regulator ...
    • The contribution of miRNA biogenesis and Myc-regulated miRNA in apoptosis and tumorigenesis 
      Adams, Clare Marie (2015-11-13)
      Department: Pathology
      microRNA (miRNA) are critical mediators of cellular signaling and regulate most biological processes. Thus, it is not surprising that miRNA dysregulation significantly contributes to tumorigenesis. In this dissertation, I ...
    • The Function of MTBP in Proliferation, Tumorigenesis and Tumor Cell Maintenance 
      Grieb, Brian Charles (2014-07-22)
      Department: Pathology
      Although the MYC transcription factor was discovered over three decades ago and is dysregulated in the majority of human cancers, its regulation remains incompletely understood and there is no pharmacologic means to inhibit ...