Browsing by Author "Christine Lovly"
Now showing items 1-4 of 4
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Gallant, Jean-Nicolas (2017-04-12)Department: Cancer BiologyLung cancer is the leading cause of cancer deaths worldwide. More than 40% of lung cancers are classified as lung adenocarcinoma (LUAD), which is defined by pathological characteristics. Oncogenic mutations in the epidermal ...
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Meador, Catherine Belle (2015-07-23)Department: Cancer BiologyEGFR-mutant lung cancers are highly sensitive to EGFR tyrosine kinase inhibitors (TKIs; erlotinib/gefitinib/afatinib), but tumors develop drug resistance within 9-16 months. Resistance to gefitinib/erlotinib commonly occurs ...
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Frick, Peter Lee (2014-11-24)Department: Chemical and Physical BiologyIntratumor heterogeneity underlies the failure of targeted cancer therapy. The origins of this phenotypic variability derive from the coincident contributions of genetic, non-genetic, and stochastic factors. However, few ...
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Childress, Merrida Ann (2018-11-16)Department: Cancer BiologyThe study of oncogenic tyrosine kinase fusions began with the discovery of the t(9:22) translocation in chronic myelogenous leukemia and its chimeric protein product, BCR-ABL. Since then, chromosomal rearrangements resulting ...