Vanderbilt University Institutional Repository: Recent submissions
Now showing items 181-200 of 17734
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(2024-03-21)Department: Molecular Physiology & BiophysicsThe studies described in this dissertation sought to better understand the role of vascular inflammation in the pathogenesis of blinding retinal disease, and explored routes to mitigate this inflammation in the pursuit of ...
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(2024-03-26)Department: Learning, Teaching & DiversityThe cradle-to-prison nexus (CTPN) refers to students from Educationally Indebted Communities (e.g., students of color that are also living below the poverty line), or EICs, are disciplined more frequently and severely than ...
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(2024-03-22)Department: ChemistryCystic fibrosis (CF) is a lethal genetic disease caused by mutations in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), an epithelial anion channel protein. CFTR variants disrupt CFTR protein folding, leading ...
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(2024-03-20)Department: Biomedical EngineeringThe tumor microenvironment is a dynamic system of cellular and extracellular components that vary in composition and interactions within and across patients. This work particularly explores the extracellular matrix (ECM) ...
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(2024-03-26)Department: Mechanical EngineeringWorkers across multiple sectors of industry are often put at risk of developing musculoskeletal disorders such as carpel tunnel syndrome, tendinitis, and lower back pain. These work-related musculoskeletal disorders stem ...
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(2024-03-25)Department: Special EducationThis dissertation consists of two studies. Study 1 was a quantitative study consisting of twelve SCDs. Study 2 consisted of a survey to evaluate expert perspectives regarding SCD practices. These studies evaluated the ...
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(2024-03-21)Department: Earth & Environmental SciencesLarge tropical mammals play a vital role in structuring ecosystems through their interactions with other species and their environments. Climate and land-use change are both causing population declines and behavioral changes ...
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(2024-03-22)Department: PharmacologyThe canonical Wnt signaling pathway is a master regulator of metazoan development and disease. The tumor suppressor APC negatively regulates Wnt pathway activation, and is conventionally thought to function primarily in ...
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(2024-03-18)Department: NeuroscienceCognitive abilities of primates, including humans, continue to develop during adolescence. Maturation of working memory in particular is considered one of the hallmarks of human cognitive development. Grasping its core ...
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(2024-03-21)Department: Cancer BiologyCancer metastasis remains a major unsolved clinical challenge as over 90% or cancer-related deaths are attributed to metastasis. Dynamic regulation of cell adhesion is crucial for successful metastatic dissemination. Cell ...
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(2024-03-20)Department: Biomedical EngineeringBreast cancer is the second-highest cancer occurrence in women in the United States and is the most prevalent cancer worldwide, with many studies dedicated to understanding its characteristics. In addition to examining ...
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(2024-03-22)Department: Mechanical EngineeringHummingbirds are perhaps the most agile flyers in nature. Studying the underlying physics of hummingbird flight may provide inspiration for developing highly maneuverable micro aerial vehicles (MAVs). In this work, we have ...
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(2024-03-18)Department: ChemistryWhile animal models are frequently used to explore the macroscale effects of various substances and processes within the blood-brain barrier (BBB), they often fail to fully recapitulate human response or prohibit mechanistic ...
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(2024-03-25)Department: AstrophysicsModeling core-collapse supernovae (CCSNe) has been an on-going effort since the 1960s. Despite advances in physics theory, physics experiments, and technology, consistent, multi-dimensional CCSN explosions are still difficult ...
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(2024-03-25)Department: Environmental EngineeringThe emergence of multiscale, nested flow systems is intrinsic to hydrologic systems across landscapes. This complex nesting and its implications for the flow of water and the transport of solutes and energy are the common ...
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(2024-03-22)Department: Political ScienceThis dissertation consists of three papers related to the differences in power {power gap} and policy preferences {alignment gap} between states in the international system. The first paper considers the issue of moral ...
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(2024-03-22)Department: EpidemiologyBreast cancer (BC) survivors, a large and growing population resulting from early detection and effective treatments, have been reported to experience faster physical and cognitive decline due to cancer and/or cancer ...
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(2024-03-21)Department: Molecular Physiology & BiophysicsThe studies described in this dissertation sought to better understand the role of vascular inflammation in the pathogenesis of blinding retinal disease, and explored routes to mitigate this inflammation in the pursuit of ...
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(2024-03-20)Department: Biomedical EngineeringThe tumor microenvironment is a dynamic system of cellular and extracellular components that vary in composition and interactions within and across patients. This work particularly explores the extracellular matrix (ECM) ...
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(2024-03-21)Department: Microbe-Host InteractionsUropathogenic Escherichia coli (UPEC) is one of the most prevalent human pathogens, causing about 80% of urinary tract infections (UTI) in the world. To establish an infection in the bladder, UPEC must survive in the ...