dc.contributor.author | Gifford, Katherine A. | |
dc.contributor.author | Liu, Dandan | |
dc.contributor.author | Neal, Jacquelyn E. | |
dc.contributor.author | Babicz, Michelle A. | |
dc.contributor.author | Thompson, Jennifer L. | |
dc.contributor.author | Walljasper, Lily E. | |
dc.contributor.author | Turchan, Maxim | |
dc.contributor.author | Pechman, Kimberly R. | |
dc.contributor.author | Osborn, Katie E. | |
dc.contributor.author | Acosta, Lealani Mae Y. | |
dc.contributor.author | Bell, Susan P. | |
dc.contributor.author | Hohman, Timothy J. | |
dc.contributor.author | Jefferson, Angela L. | |
dc.date.accessioned | 2020-04-06T21:22:08Z | |
dc.date.available | 2020-04-06T21:22:08Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Gifford , K. A. , Liu , D. , Neal , J. E. , Babicz , M. A. , Thompson , J. L. , Walljasper , L. E. , … Jefferson , A. L . (2018 ). The 12-word Philadelphia Verbal Learning Test performances in older adults: Brain MRI and cerebrospinal fluid correlates and regression-based normative data . Dementia and Geriatric Cognitive Disorders Extra , 8, 476–491 . doi:10.1159/000494209 | en_US |
dc.identifier.issn | 1664-5464 | |
dc.identifier.uri | https://ir.vanderbilt.edu/xmlui/handle/1803/9893 | |
dc.description | Only Vanderbilt University affiliated authors are listed on VUIR. For a full list of authors, access the version of record at https://app.dimensions.ai/details/publication/pub.1110428700?and_facet_journal=jour.1045419 | en_US |
dc.description.abstract | Background/Aims: This study evaluated neuroimaging and biological correlates, psychometric properties, and regression-based normative data of the 12-word Philadelphia Verbal Learning Test (PVLT), a list-learning test. Methods: Vanderbilt Memory and Aging Project participants free of clinical dementia and stroke (n = 230, aged 73 +/- 7 years) completed a neuropsychological protocol and brain MRI. A subset (n = 111) underwent lumbar puncture for analysis of Alzheimer's disease (AD) and axonal integrity cerebrospinal fluid (CSF) biomarkers. Regression models related PVLT indices to MRI and CSF biomarkers adjusting for age, sex, race/ethnicity, education, APOE-epsilon 4 carrier status, cognitive status, and intracranial volume (MRI models). Secondary analyses were restricted to participants with normal cognition (NC; n = 127), from which regression-based normative data were generated. Results: Lower PVLT performances were associated with smaller medial temporal lobe volumes (p < 0.05) and higher CSF tau concentrations (p < 0.04). Among NC, PVLT indices were associated with white matter hyperintensities on MRI and an axonal injury biomarker (CSF neurofilament light; p < 0.03). Conclusion: The PVLT appears sensitive to markers of neurodegeneration, including temporal regions affected by AD. Conversely, in cognitively normal older adults, PVLT performance seems to relate to white matter disease and axonal injury, perhaps reflecting non-AD pathways to cognitive change. Enhanced normative data enrich the clinical utility of this tool. (C) 2018 The Author(s) Published by S. Karger AG, Basel | en_US |
dc.description.sponsorship | We thank the patients and their families, whose help and participation made this work possible. This work was supported by the Paul B. Beeson Career Development Award in Aging K23-AG030962 (A.L.J.); K24-AG046373 (A.L.J.); Alzheimer's Association IIRG-08-88733 (A. L. J); R01-AG034962 (A.L.J.); R01-AG056534 (A.L.J.); R01-NS100980 (A.L.J.); K12-HD043483 (K.A.G., T.J.H., S.P.B.); Alzheimer's Association NIRG-13-283276 (K.A.G.); K23-AG045966 (K.A.G.); Paul B. Beeson Career Development Award in Aging K23-AG048347 (S.P.B.); the Eisenstein Women's Heart Fund (S.B.P.); K01-AG049164 (T.J.H.); F32-AG058395 (K.E.O.); Vanderbilt Institute for Clinical and Translational Research UL1-TR000445; Vanderbilt's High-Performance Computer Cluster for Biomedical Research S10-OD023680; the Vanderbilt Memory and Alzheimer's Center; the Swedish Research Council; the Swedish Alzheimer's Association; the Knut and Alice Wallenberg Foundation, and Torsten Soderberg Foundation, Stockholm, Sweden. | en_US |
dc.publisher | DEMENTIA AND GERIATRIC COGNITIVE DISORDERS EXTRA | en_US |
dc.rights | This article is licensed under the Creative Commons Attribution-NonCommercial-No Derivatives 4.0 International
License (CC BY-NC-ND) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution
for commercial purposes as well as any distribution of modified material requires written permission | |
dc.source.uri | https://app.dimensions.ai/details/publication/pub.1110428700?and_facet_journal=jour.1045419 | |
dc.subject | Aging | en_US |
dc.subject | Alzheimer's disease | en_US |
dc.subject | Biomarkers | en_US |
dc.subject | Episodic memory | en_US |
dc.subject | Psychometrics | en_US |
dc.subject | Normative data | en_US |
dc.subject | Structural neuroimaging | en_US |
dc.subject | Temporal lobe | en_US |
dc.subject | White matter hyperintensities | en_US |
dc.subject | Cerebrospinal fluid | en_US |
dc.title | The 12-Word Philadelphia Verbal Learning Test Performances in Older Adults: Brain MRI and Cerebrospinal Fluid Correlates and Regression-Based Normative Data | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1159/000494209 | |