Browsing Electronic Theses and Dissertations by Author "J. Scott Daniels"
Now showing items 1-5 of 5
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Crouch, Rachel Denise (2016-11-28)Department: PharmacologyUnacceptable pharmacokinetics (PK) relating to aldehyde oxidase (AO) metabolism have resulted in clinical failure of several promising drug candidates, yet reliable and standardized methods to predict the human PK and ...
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Schulte, Michael Lawrence (2013-08-01)Department: ChemistryAziridines represent an important class of nitrogen-containing heterocycles with a wide range of synthetic utility. Despite their value, synthetic approaches are limited in terms of generality and diversity. On this ...
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Gordon, Odaine Narado (2014-04-19)Department: PharmacologyThe dietary polyphenol curcumin shows great promise as an anti-cancer and anti-inflammatory agent. While many cellular targets of curcumin have been identified, the chemical mechanisms whereby these targets are affected ...
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Brogan, John Trevor (2013-07-29)Department: Chemical and Physical BiologyThe first total synthesis of (+)-7-bromotrypargine, a β-carboline alkaloid from Ancornia sp. was completed in 9 steps, 8 steps longest linear sequence, and 40% overall yield. Biological characterization found that ...
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Garcia Barrantes, Pedro Manuel (2016-11-08)Department: Chemical and Physical BiologyThe first total synthesis of Gombamide A, a cyclic thiopeptide from the sponge Clathria gombawuiensis, is reported. The convergent synthesis features a disulfide bond forming cascade to close the 17-membered macrocycle and ...